EP 1491889 A2 20041229 - Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-beta peptide (x = 41) and tau
Title (en)
Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-beta peptide (x = 41) and tau
Title (de)
Verfahren zur Unterstützung der Diagnose der Alzheimerschen Krankheit durch Messung der Amyloid-Beta-Peptide(x =41) und Tau
Title (fr)
Méthode d'assistance au diagnostic de la maladie d'alzheimer par mesure du peptide amyloide-beta (x = 41) et de la protéine tau
Publication
Application
Priority
- EP 95939892 A 19951113
- US 33914194 A 19941114
- US 41900895 A 19950407
Abstract (en)
This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid- beta peptide (x-≥41) in the cerebrospinal fluid of a patient. High levels of the peptide generally are inconsistent with a diagnosis of Alzheimer's. Low levels of the peptide are consistent with the disease and, with other tests, can provide a positive diagnosis. Other methods involve measuring the amounts of both A beta (x-≥41) and tau. Low levels of A beta (x-≥41) and high levels of tau are a positive indicator of Alzheimer's disease, while high levels of A beta (x-≥41) and low levels of tau are a negative indication of Alzheimer's disease. <IMAGE>
Diagnosis and monitoring of Alzheimer's disease (AD) is aided by: (a) measuring the amount of at least one soluble Abeta (x->= 41) peptide (I) in a test sample; (b) comparing the result with a predetermined amount of the same peptide; and (c) assessing patient status from the difference.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 15/09 (2006.01); G01N 33/537 (2006.01); G01N 33/542 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
C07K 14/4711 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); G01N 33/6896 (2013.01 - EP US); G01N 2333/4709 (2013.01 - EP US); G01N 2500/00 (2013.01 - EP US); G01N 2800/2821 (2013.01 - EP US); Y10S 436/811 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9615452 A1 19960523; AT E278957 T1 20041015; AU 4154496 A 19960606; AU 705907 B2 19990603; CA 2205359 A1 19960523; CA 2205359 C 20060704; DE 69533623 D1 20041111; DE 69533623 T2 20060302; DK 0792458 T3 20050131; EP 0792458 A1 19970903; EP 0792458 A4 19990407; EP 0792458 B1 20041006; EP 1491889 A2 20041229; EP 1491889 A3 20050406; ES 2230551 T3 20050501; JP 2004077499 A 20040311; JP 3634375 B2 20050330; JP H10509797 A 19980922; PT 792458 E 20050228; US 2004253643 A1 20041216; US 2004265920 A1 20041230; US 2005069968 A1 20050331; US 7427392 B1 20080923; US 7700309 B2 20100420; US 7811769 B2 20101012
DOCDB simple family (application)
US 9514659 W 19951113; AT 95939892 T 19951113; AU 4154496 A 19951113; CA 2205359 A 19951113; DE 69533623 T 19951113; DK 95939892 T 19951113; EP 04077711 A 19951113; EP 95939892 A 19951113; ES 95939892 T 19951113; JP 2003391483 A 20031120; JP 51622096 A 19951113; PT 95939892 T 19951113; US 46655495 A 19950606; US 87768804 A 20040625; US 87995804 A 20040628; US 96448404 A 20041012