EP 1492537 A1 20050105 - MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
Title (en)
MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
Title (de)
MORPHOLIN-DERIVATE MIT EINER SUBSTITUIERTEN ACETAMID-GRUPPE IN 2-POSITION ZUR VERWENDUNG ALS CCR-3 ANTAGONISTEN ZUR BEHANDLUNG VON ENTZÜNDLICHEN ERKRANKUNGEN
Title (fr)
DERIVES DE MORPHOLINE COMPRENANT UN GROUPE ACETAMIDE SUBSTITUE EN POSITION 2 UTILISES EN TANT QU'ANTAGONISTES DE CCR-3 DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES
Publication
Application
Priority
- EP 0303348 W 20030327
- GB 0207443 A 20020328
Abstract (en)
[origin: WO03082294A1] Certain compounds of formula (I); wherein R1 represents substituted or unsubstituted aryl; X represents -O- or a bond; Y represents -(CRna,Rnb) n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5; R<2> represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R<3> represents hydrogen or C1-6alkyl; R<10> represents hydrogen or C1-6alkyl; and salts and solvates thereof are CCR3 antagonists and are therefore indicated to be useful in therapy of inflammatory conditions.
IPC 1-7
A61K 31/5377; A61K 31/5375; A61P 29/00; A61P 11/06; C07D 265/30; C07D 413/12; C07D 413/06; C07D 209/48
IPC 8 full level
A61P 11/06 (2006.01); A61P 29/00 (2006.01); C07D 209/48 (2006.01); C07D 265/30 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01)
CPC (source: EP)
A61P 11/02 (2017.12); A61P 11/06 (2017.12); A61P 17/00 (2017.12); A61P 29/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07D 209/48 (2013.01); C07D 265/30 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01)
Citation (search report)
See references of WO 03082294A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03082294 A1 20031009; AR 039174 A1 20050209; AU 2003226762 A1 20031013; EP 1492537 A1 20050105; GB 0207443 D0 20020508; JP 2006504625 A 20060209; TW 200404000 A 20040316
DOCDB simple family (application)
EP 0303348 W 20030327; AR P030101087 A 20030327; AU 2003226762 A 20030327; EP 03745299 A 20030327; GB 0207443 A 20020328; JP 2003579831 A 20030327; TW 92106771 A 20030326