EP 1495002 B1 20120905 - BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS
Title (en)
BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS
Title (de)
BENZAMID-DERIVATE VERWENDBAR ALS HISTON-DEACETYLASE-INHIBITOREN
Title (fr)
DÉRIVÉS DE BENZAMIDE UTILES EN TANT QU'INHIBITEURS D'HISTONE DEACETYLASE
Publication
Application
Priority
- GB 0301442 W 20030402
- GB 0207863 A 20020405
- GB 0229930 A 20021221
Abstract (en)
[origin: WO03087057A1] The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R<1> is a group such as hydroxy, halo, trifluoromethyl and cyano; R<2> is halo and n is 0-2; and each R<4> is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R<3> is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by histone deacetylase.
IPC 8 full level
C07D 213/56 (2006.01); C07D 251/14 (2006.01); A61K 31/341 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/435 (2006.01); A61K 31/4365 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/444 (2006.01); A61K 31/445 (2006.01); A61K 31/4465 (2006.01); A61K 31/4525 (2006.01); A61K 31/453 (2006.01); A61K 31/454 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/495 (2006.01); A61K 31/4965 (2006.01); A61K 31/497 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61P 7/06 (2006.01); A61P 25/14 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 211/34 (2006.01); C07D 213/74 (2006.01); C07D 215/12 (2006.01); C07D 237/08 (2006.01); C07D 239/26 (2006.01); C07D 239/42 (2006.01); C07D 241/12 (2006.01); C07D 241/18 (2006.01); C07D 241/20 (2006.01); C07D 251/18 (2006.01); C07D 277/20 (2006.01); C07D 277/24 (2006.01); C07D 277/30 (2006.01); C07D 295/14 (2006.01); C07D 295/155 (2006.01); C07D 307/54 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 407/06 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP KR US)
A61P 7/06 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 211/34 (2013.01 - EP US); C07D 213/56 (2013.01 - EP KR US); C07D 213/74 (2013.01 - EP US); C07D 215/12 (2013.01 - EP US); C07D 237/08 (2013.01 - EP US); C07D 239/26 (2013.01 - EP US); C07D 239/42 (2013.01 - EP US); C07D 241/20 (2013.01 - EP US); C07D 251/18 (2013.01 - EP US); C07D 277/24 (2013.01 - EP US); C07D 277/30 (2013.01 - EP US); C07D 295/155 (2013.01 - EP US); C07D 307/54 (2013.01 - EP US); C07D 401/04 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US); C07D 401/12 (2013.01 - KR); C07D 403/12 (2013.01 - EP US); C07D 405/06 (2013.01 - EP US); C07D 409/04 (2013.01 - EP US); C07D 417/06 (2013.01 - EP US); C07D 487/04 (2013.01 - EP KR US); C07D 495/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated extension state (EPC)
AL LT LV
DOCDB simple family (publication)
WO 03087057 A1 20031023; AR 039257 A1 20050216; AU 2003217054 A1 20031027; AU 2003217054 B2 20090129; BR 0308875 A 20050104; CA 2480356 A1 20031023; CA 2480356 C 20120103; CN 101805309 A 20100818; CN 1642915 A 20050720; CY 1113483 T1 20160622; DK 1495002 T3 20121203; EG 25655 A 20120502; EP 1495002 A1 20050112; EP 1495002 B1 20120905; ES 2392963 T3 20121217; HK 1071359 A1 20050715; IL 164373 A0 20051218; IL 164373 A 20110228; IS 2895 B 20140915; IS 7483 A 20041001; JP 2005533011 A 20051104; JP 4471665 B2 20100602; KR 101066508 B1 20110921; KR 20040111478 A 20041231; MX PA04009689 A 20050111; MY 142177 A 20101015; NO 20044444 L 20041228; NO 330119 B1 20110221; NZ 535143 A 20070427; PL 372967 A1 20050808; PT 1495002 E 20121126; RU 2004132844 A 20050610; RU 2376287 C2 20091220; SI 1495002 T1 20121231; TW 200400167 A 20040101; TW I319387 B 20100111; US 2005171103 A1 20050804; US 2009029991 A1 20090129; US 2010331329 A1 20101230; US 8247562 B2 20120821
DOCDB simple family (application)
GB 0301442 W 20030402; AR P030101185 A 20030404; AU 2003217054 A 20030402; BR 0308875 A 20030402; CA 2480356 A 20030402; CN 03807431 A 20030402; CN 201010144649 A 20030402; CY 121101133 T 20121122; DK 03712442 T 20030402; EG NA2004000099 A 20041003; EP 03712442 A 20030402; ES 03712442 T 20030402; HK 05104103 A 20050517; IL 16437303 A 20030402; IL 16437304 A 20041003; IS 7483 A 20041001; JP 2003584013 A 20030402; KR 20047015754 A 20030402; MX PA04009689 A 20030402; MY PI20031256 A 20030403; NO 20044444 A 20041019; NZ 53514303 A 20030402; PL 37296703 A 20030402; PT 03712442 T 20030402; RU 2004132844 A 20030402; SI 200332207 T 20030402; TW 92106629 A 20030325; US 21151008 A 20080916; US 50994104 A 20041001; US 87936710 A 20100910