EP 1495117 A4 20050608 - HUMAN DEUBIQUITINATING PROTEASE GENE ON CHROMOSOME 7 AND ITS MURINE ORTHOLOG
Title (en)
HUMAN DEUBIQUITINATING PROTEASE GENE ON CHROMOSOME 7 AND ITS MURINE ORTHOLOG
Title (de)
MENSCHLICHES DEUBIQUITINIERUNGSPROTEASE-GEN AUF CHROMOSOM 7 UND SEIN MAUS-ORTHOLOG
Title (fr)
GENE HUMAIN DE LA PROTEASE DE DESUBIQUITINATION POSITIONNEE SUR LE CHROMOSOME 7 ET SON ORTHOLOGUE MURIN
Publication
Application
Priority
- GB 0218518 A 20020809
- US 0308590 W 20030321
- US 36660102 P 20020322
Abstract (en)
[origin: WO03083050A2] Human and murine analogs of DUBs, hematopoietic-specific, cytokine-inducible deubiquitinating proteases, clustered on chromosome 7 and their respective regulatory regions are identified. The nucleotide or proteins encoded thereby may be used in assays to identify inhibitors of hDUB7 or mDUB7. The invention also includes transducing peptides comprising an NLS or transducing sequence of hDUB7 or mDUB7 linked to a cargo molecule, and methods of delivering a biologically active protein, therapeutically effective compound, antisense nucleotide, or test compound to a cell wherein a transducing peptide is added exogenously to a cell.
IPC 1-7
C12N 9/64; C12N 15/57; C12N 15/62; C12Q 1/37; C12Q 1/68; A61K 38/48
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); C12N 5/07 (2010.01); C12N 5/078 (2010.01); C12N 9/64 (2006.01); C12N 15/87 (2006.01); C12Q 1/37 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 37/02 (2017.12); A61P 43/00 (2017.12); C12N 9/6472 (2013.01); C12N 15/87 (2013.01); C12Q 1/37 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); G01N 2500/04 (2013.01)
Citation (search report)
- [X] WO 0123589 A2 20010405 - MILLENNIUM PHARM INC [US], et al
- [X] WO 0110903 A2 20010215 - INCYTE GENOMICS INC [US], et al
- [X] WO 9706247 A2 19970220 - DANA FARBER CANCER INST INC [US], et al
- [A] BAKER R T ET AL: "Identification, Functional Characterization, and Chromosomal Localization of USP15, a Novel Human Ubiquitin-Specific Protease Related to the UNP Oncoprotein, and a Systematic Nomenclature for Human Ubiquitin-Specific Proteases", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 59, no. 3, 1 August 1999 (1999-08-01), pages 264 - 274, XP004444843, ISSN: 0888-7543
- [A] JANS D A ET AL: "SIGNALS MEDIATING NUCLEAR TARGETING AND THEIR REGULATION: APPLICATION IN DRUG DELIVERY", MEDICINAL RESEARCH REVIEWS, NEW YORK, NY, US, vol. 18, no. 4, July 1998 (1998-07-01), pages 189 - 223, XP002922553, ISSN: 0198-6325
- See references of WO 03083050A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03083050 A2 20031009; WO 03083050 A3 20040226; AU 2003230701 A1 20031013; AU 2003230701 B2 20080605; AU 2003230701 C1 20090827; BR 0307759 A 20041221; CA 2479647 A1 20031009; EP 1495117 A2 20050112; EP 1495117 A4 20050608; IL 164088 A0 20051218; JP 2005520567 A 20050714; MX PA04006975 A 20041110
DOCDB simple family (application)
US 0308590 W 20030321; AU 2003230701 A 20030321; BR 0307759 A 20030321; CA 2479647 A 20030321; EP 03723791 A 20030321; IL 16408803 A 20030321; JP 2003580486 A 20030321; MX PA04006975 A 20030321