EP 1495124 A2 20050112 - SMAC-PEPTIDES AS THERAPEUTICS AGAINST CANCER AND AUTOIMMUNE DISEASES
Title (en)
SMAC-PEPTIDES AS THERAPEUTICS AGAINST CANCER AND AUTOIMMUNE DISEASES
Title (de)
SMAC-PEPTIDE ZUR VERWENDUNG ALS THERAPEUTISCHE MITTEL GEGEN KREBS UND AUTOIMMUNERKRANKUNGEN
Title (fr)
PEPTIDES-SMAC COMME AGENTS THERAPEUTIQUES CONTRE LE CANCER ET LES MALADIES AUTO-IMMUNES
Publication
Application
Priority
- EP 03722503 A 20030417
- EP 0304039 W 20030417
- EP 02008199 A 20020417
- EP 02015499 A 20020712
Abstract (en)
[origin: WO03086470A2] The invention is directed to the use of Smac to sensitize different tumors and self-reactive immune cells to various pro-apoptosic stimuli, in that the cells subsequently undergo apoptosis. Therefore, Smac can be used as a compound for the manufacture of a medicament for the treatment of cancer and autoimmune diseases. Sensitization of the cells is achieved either by applying a cell-permeable form of Smac combined with known anticancer agents or by overexpression of the protein. It is an object of the invention to provide a new method in cancer and autoimmune disease therapy by using Smac agonists for apoptosis regulation. Thus, Smac agonists represent novel promising cancer and autoimmune disease therapeutics to potentiate the efficacy of cytotoxic therapies even in resistant tumors and immune cells.
IPC 1-7
C12N 15/12; C12N 15/62; A61K 47/48; C07K 5/103; C07K 19/00; C07K 14/47; A61K 38/17; C07K 5/10; A61K 41/00
IPC 8 full level
A61K 38/17 (2006.01); A61K 47/48 (2006.01); C07K 5/103 (2006.01); C07K 14/47 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 38/17 (2013.01); A61K 47/64 (2017.07); C07K 5/1008 (2013.01); C07K 14/4747 (2013.01); C07K 2319/00 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 03086470A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03086470 A2 20031023; WO 03086470 A3 20040506; EP 1495124 A2 20050112
DOCDB simple family (application)
EP 0304039 W 20030417; EP 03722503 A 20030417