EP 1495323 A2 20050112 - METHOD FOR CLEAVING AND DEGLYCOSYLATING ANTIBODIES TO PROMOTE LIGAND BINDING
Title (en)
METHOD FOR CLEAVING AND DEGLYCOSYLATING ANTIBODIES TO PROMOTE LIGAND BINDING
Title (de)
VERFAHREN ZUM ABSPALTEN UND DEGLYKOSILIERUNG VON ANTIKÖRPER FÜR VERBESSERTEN LIGANDENBINDUNG
Title (fr)
PROCEDE DE CLIVAGE ET DE DEGLYCOSYLATION D'ANTICORPS POUR PROMOUVOIR UNE LIAISON DE LIGAND
Publication
Application
Priority
- US 0310673 W 20030407
- US 37058902 P 20020405
Abstract (en)
[origin: WO03087821A2] The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to remove the carbohydrate moiety, and orienting the cleaved fragment on a matrix to enhance recognition of a ligand are also described. Methods of differentiating pregnancy-derived and disease derived samples are also described.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); G01N 33/574 (2006.01); G01N 33/76 (2006.01)
CPC (source: EP)
A61K 47/6811 (2017.07); G01N 33/574 (2013.01); G01N 33/76 (2013.01); G01N 2333/42 (2013.01); G01N 2333/95 (2013.01); G01N 2400/02 (2013.01)
Citation (search report)
See references of WO 03087821A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03087821 A2 20031023; WO 03087821 A3 20040819; AU 2003221671 A1 20031027; CA 2481420 A1 20031023; EP 1495323 A2 20050112
DOCDB simple family (application)
US 0310673 W 20030407; AU 2003221671 A 20030407; CA 2481420 A 20030407; EP 03718249 A 20030407