EP 1497305 A2 20050119 - INSULIN-RESPONSIVE DNA BINDING PROTEIN-1 AND METHODS TO REGULATE INSULIN-RESPONSIVE GENES
Title (en)
INSULIN-RESPONSIVE DNA BINDING PROTEIN-1 AND METHODS TO REGULATE INSULIN-RESPONSIVE GENES
Title (de)
AUF INSULIN REAGIERENDE DNA BINDENDES PROTEIN 1 UND VERFAHREN ZUR REGULATION AUF INSULIN REAGIERENDER GENE
Title (fr)
PROTEINE 1 DE LIAISON A L'ADN SENSIBLE A L'INSULINE ET METHODES DESTINEES A REGULER DES GENES SENSIBLES A L'INSULINE
Publication
Application
Priority
- US 0238595 W 20021204
- US 33658501 P 20011204
- US 39000002 P 20020618
Abstract (en)
[origin: WO03057827A2] The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 IRDBP-1 and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that respond when cells are exposed to insulin. IRDBP-1 regulates genes important in mediating the insulin response in mamals and in regulating conditions such as diabetes, obesity, insulin-resistant syndrome and cell proliferative disorders. The present invention provides nucleic acids useful as probes for detecting nucleic acids encoding regions of the IRDBP-1 protein. Within the scope of the present invention are recombinant cells, tissues and animals containing non-naturally occurring recombinant nucleic acid molecules encoding IRDBP-1, including expression vectors, antibodies specific for IRDBP-1, assays for IRDBP-1 polypeptide, and methods relating to all of the foregoing, the development of therapeutic and diagnostic agents that mimic, facilitate or inhibit the actionof IRDBP-1, and/or are based on relationships ot the structure and action of IRDBP-1.
[origin: WO03057827A2] The present invention relates to the novel protein Insulin−Responsive DNA Binding Protein−1 (IRDBP−1) and nucleotide sequences that encode it. IRDBP−1 binds to nucleic acid regions of genes that respond when cells are exposed to insulin. IRDBP−1 regulates genes important in mediating the insulin response in mamals and in regulating conditions such as diabetes, obesity, insulin−resistant syndrome and cell proliferative disorders. The present invention provides nucleic acids useful as probes for detecting nucleic acids encoding regions of the IRDBP−1 protein. Within the scope of the present invention are recombinant cells, tissues and animals containing non−naturally occurring recombinant nucleic acid molecules encoding IRDBP−1, including expression vectors, antibodies specific for IRDBP−1, assays for IRDBP−1 polypeptide, and methods relating to all of the foregoing, the development of therapeutic and diagnostic agents that mimic, facilitate or inhibit the actionof IRDBP−1, and/or are based on relationships ot the structure and action of IRDBP−1.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C07K 16/18 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61P 3/10 (2017.12); C07K 14/4702 (2013.01); C07K 16/18 (2013.01); A01K 2217/075 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03057827 A2 20030717; WO 03057827 A3 20041028; AU 2002359580 A1 20030724; CA 2469177 A1 20030717; EP 1497305 A2 20050119; EP 1497305 A4 20051130
DOCDB simple family (application)
US 0238595 W 20021204; AU 2002359580 A 20021204; CA 2469177 A 20021204; EP 02794127 A 20021204