EP 1499343 A1 20050126 - A METHOD OF MODULATING CELLULAR ACTIVITY
Title (en)
A METHOD OF MODULATING CELLULAR ACTIVITY
Title (de)
VERFAHREN ZUR MODULIERUNG DER ZELLAKTIVITÄT
Title (fr)
METHODE DE MODULATION D'ACTIVITE CELLULAIRE
Publication
Application
Priority
- AU 0300388 W 20030328
- AU PS144802 A 20020328
- AU PS153802 A 20020405
- AU PS162102 A 20020408
- AU 2002951668 A 20020919
- AU 2003900230 A 20030121
Abstract (en)
[origin: WO03082322A1] The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating cellular activity by modulating phosphorylation of sphingosine kinase and, thereby, its activation. In a related aspect, the present invention provides a method of modulating sphingosine kinase functional activity via modulation of its phosphorylation and agents for use therein. The present invention still further extends to sphingosine kinase variants and to functional derivatives, homologues or analogues, chemical equivalents and mimetics thereof exhibiting reduced and/or ablated capacity to undergo phosphorylation. The method and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular and/or sphingosine kinase functional activity. The present invention is further directed to methods for identifying and/or designing agents capable of modulating sphingosine kinase phosphorylation.
IPC 1-7
A61K 38/43; A61K 38/18; A61K 38/19; A61K 38/00; A61P 29/00; A61P 35/00; A61P 37/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/43 (2006.01); A61K 45/00 (2006.01); A61P 1/04 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07K 16/40 (2006.01); C12N 9/12 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 9/10 (2017.12); A61P 11/06 (2017.12); A61P 19/02 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C07K 16/40 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03082322 A1 20031009; AU 2003215426 A1 20031013; AU 2009201639 A1 20090521; CA 2480661 A1 20031009; EP 1499343 A1 20050126; EP 1499343 A4 20051228; JP 2005526809 A 20050908
DOCDB simple family (application)
AU 0300388 W 20030328; AU 2003215426 A 20030328; AU 2009201639 A 20090424; CA 2480661 A 20030328; EP 03745226 A 20030328; JP 2003579859 A 20030328