EP 1499628 A2 20050126 - RNA INTERFERENCE MEDIATED INHIBITION OF STEAROYL-COA DESATURASE (SCD) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
Title (en)
RNA INTERFERENCE MEDIATED INHIBITION OF STEAROYL-COA DESATURASE (SCD) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
Title (de)
RNA-INTERFERENZ-VERMITTELTE HEMMUNG DER EXPRESSION DES STEAROYL-COA-DESATURASE (SCD)-GENS UNTER VERWENDUNG VON SINA (SHORT INTERFERING NUCLEIC ACID)
Title (fr)
INHIBITION MEDIEE DE L'INTERFERENCE D'ARN DE L'EXPRESSION DU GENE DE LA STEAROYL-COA DESATURASE (SCD) AU MOYEN D'ACIDES NUCLEIQUES D'INTERFERENCE COURTS
Publication
Application
Priority
- US 0304317 W 20030213
- US 35858002 P 20020220
- US 36312402 P 20020311
- US 38678202 P 20020606
- US 40678402 P 20020829
- US 40837802 P 20020905
- US 40929302 P 20020909
- US 41230402 P 20020920
- US 44012903 P 20030115
Abstract (en)
[origin: WO03070885A2] The present invention concerns methods and reagents useful in modulating Stearoyl-CoA desaturase (SCD) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against Steraroyl-CoA desaturase (SCD) gene expression and/or activity. The siNA molecules are useful in the treatment of diabetes (type I and/or type II), atherosclerosis, cancer, obesity, and viral infection, and any other condition that responds to modulation of SCD expression or activity.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 47/54 (2017.07); C12N 15/1132 (2013.01); C12N 15/1137 (2013.01); C12N 15/115 (2013.01); C12Y 114/19001 (2013.01); C12Y 207/11001 (2013.01); C12Y 207/11013 (2013.01); C12Y 301/03048 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/12 (2013.01); C12N 2310/121 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/317 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/332 (2013.01); C12N 2310/346 (2013.01); C12N 2310/53 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03070885 A2 20030828; WO 03070885 A3 20041111; AU 2003215203 A1 20030909; AU 2003215203 A8 20030909; EP 1499628 A2 20050126; EP 1499628 A4 20050615
DOCDB simple family (application)
US 0304317 W 20030213; AU 2003215203 A 20030213; EP 03711017 A 20030213