EP 1499728 A2 20050126 - NUCLEOTIDE SEQUENCE CODING FOR A MANNITOL 2-DEHYDROGENASE AND METHOD FOR THE PRODUCTION OF D-MANNITOL
Title (en)
NUCLEOTIDE SEQUENCE CODING FOR A MANNITOL 2-DEHYDROGENASE AND METHOD FOR THE PRODUCTION OF D-MANNITOL
Title (de)
FÜR EINE MANNITOL-2-DEHYDROGENASE CODIERENDE NUKLEOTIDSEQUENZ SOWIE VERFAHREN ZUR HERSTELLUNG VON D-MANNITOL
Title (fr)
SEQUENCE NUCLEOTIDIQUE CODANT POUR UNE MANNITOL-2-DESHYDROGENASE ET PROCEDE DE PRODUCTION DE D-MANNITOL
Publication
Application
Priority
- DE 0301456 W 20030506
- DE 10220848 A 20020508
Abstract (en)
[origin: WO03095635A2] The invention relates to a nucleotide sequence coding for the mannitol 2-dehydrogenase and a method for producing D-mannitol. Previously known biocatalytic methods for producing D-mannitol yield only small production rates due to the small number of specific activities of mannitol 2-dehydrogenases used for transforming D-fructose into D-mannitol. D-mannitol production can be improved by supplying a nucleotide sequence which codes for a mannitol 2-dehydrogenase having a higher specific activity. Mannitol production can be increased in a particular manner by creating a regeneration system for reduction equivalents by introducing and/or strengthening a formiate dehydrogenase in a microorganism.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 9/04 (2006.01); C12P 7/18 (2006.01)
CPC (source: EP US)
C12N 9/0006 (2013.01 - EP US); C12P 7/18 (2013.01 - EP US)
Citation (search report)
See references of WO 03095635A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03095635 A2 20031120; WO 03095635 A3 20040422; AU 2003245816 A1 20031111; CA 2485489 A1 20031120; DE 10220848 A1 20031204; EP 1499728 A2 20050126; JP 2005528098 A 20050922; US 2005239180 A1 20051027
DOCDB simple family (application)
DE 0301456 W 20030506; AU 2003245816 A 20030506; CA 2485489 A 20030506; DE 10220848 A 20020508; EP 03737872 A 20030506; JP 2004503628 A 20030506; US 51403105 A 20050525