EP 1501869 A4 20060111 - PHOSPHORYLATED HISTONE H2B AS AN APOPTOSIS MARKER

Title (en)

PHOSPHORYLATED HISTONE H2B AS AN APOPTOSIS MARKER

PHOSPHORYLIERTES HISTON H2B ALS APOPTOSEMARKER

HISTONE H2B PHOSPHORYLEE UTILISEE COMME MARQUEUR DE L'APOPTOSE

C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); G01N 33/53 (2006.01)

C07K 16/18 (2013.01); C07K 16/44 (2013.01); C12Q 1/485 (2013.01); C07K 2317/82 (2013.01); G01N 2440/14 (2013.01); G01N 2500/04 (2013.01); G01N 2510/00 (2013.01)

[X] WO 9211029 A1 19920709 - UNIV JOHNS HOPKINS [US]
[X] GB 2241782 A 19910911 - MORINAGA & CO [JP]
[X] US 5637465 A 19970610 - TRAUTH BERNHARD [DE]
[AD] AJIRO KOZO: "Histone H2B phosphorylation in mammalian apoptotic cells: An association with DNA fragmentation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 1, 7 January 2000 (2000-01-07), pages 439 - 443, XP002353258, ISSN: 0021-9258
[T] CHEUNG WANG L ET AL: "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.", CELL, vol. 113, no. 4, 16 May 2003 (2003-05-16), pages 507 - 517, XP002353259, ISSN: 0092-8674
See references of WO 03014142A2

GRAVES J D ET AL: "Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 4 MAY 2001, vol. 276, no. 18, 4 May 2001 (2001-05-04), pages 14909 - 14915, ISSN: 0021-9258
CHEUNG P; ALLIS C D; SASSONE-CORSI P: "Signaling to chromatin through histone modifications.", CELL, vol. 103, no. 2, 13 October 2000 (2000-10-13), US, pages 263 - 271

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EP 02756877 A 20020801