EP 1507552 A2 20050223 - METHODS, COMPOSITIONS, AND GROWTH AND DIFFERENTIATION FACTORS FOR INSULIN-PRODUCING CELLS
Title (en)
METHODS, COMPOSITIONS, AND GROWTH AND DIFFERENTIATION FACTORS FOR INSULIN-PRODUCING CELLS
Title (de)
VERFAHREN, ZUSAMMENSETZUNGEN UND WACHSTUMS- UND DIFFERENZIERUNGSFAKTOREN FÜR INSULINPRODUZIERENDE ZELLEN
Title (fr)
PROCEDES, COMPOSITIONS ET FACTEURS DE CROISSANCE ET DE DIFFERENCIATION POUR CELLULES PRODUCTRICES D'INSULINE
Publication
Application
Priority
- US 0316734 W 20030528
- US 38400002 P 20020528
- US 44373303 A 20030522
Abstract (en)
[origin: WO03100026A2] A method of converting differentiated non-hormone producing pancreatic cells into differentiated hormone producing cells is disclosed. The method comprises two steps: first, culturing cells under conditions which convert differentiated non-hormone producing cells into stem cells; and second, culturing stem cells under conditions which provide for differentiating stem cells into hormone-producing cells. The invention defines growth and differentiation factors that are presented to the stem cells to result in their differentiation into hormone-producing cells, especially insulin-producing cells. The invention provides a new source of large quantities of hormone producing cells such as insulin-producing cells that are not currently available for therapeutic uses such as the treatment of diabetes.
IPC 1-7
A61K 38/16; A61K 38/19; A01N 1/02; C12N 5/00; C07K 5/00; C07K 14/00
IPC 8 full level
C12N 5/071 (2010.01); A61K 35/12 (2015.01)
CPC (source: EP)
C12N 5/0676 (2013.01); A61K 2035/126 (2013.01); C12N 2500/25 (2013.01); C12N 2500/38 (2013.01); C12N 2500/46 (2013.01); C12N 2500/90 (2013.01); C12N 2501/01 (2013.01); C12N 2501/105 (2013.01); C12N 2501/11 (2013.01); C12N 2501/113 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/12 (2013.01); C12N 2501/135 (2013.01); C12N 2501/148 (2013.01); C12N 2501/15 (2013.01); C12N 2501/16 (2013.01); C12N 2501/165 (2013.01); C12N 2501/235 (2013.01); C12N 2501/315 (2013.01); C12N 2501/335 (2013.01); C12N 2501/34 (2013.01); C12N 2501/345 (2013.01); C12N 2501/35 (2013.01); C12N 2501/37 (2013.01); C12N 2501/39 (2013.01); C12N 2501/392 (2013.01); C12N 2501/41 (2013.01); C12N 2501/83 (2013.01); C12N 2501/85 (2013.01); C12N 2501/998 (2013.01); C12N 2506/22 (2013.01)
Citation (search report)
See references of WO 03100026A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03100026 A2 20031204; WO 03100026 A3 20041104; AU 2003240810 A1 20031212; BR 0311362 A 20061031; CA 2487858 A1 20031204; CN 1668324 A 20050914; EP 1507552 A2 20050223; JP 2006506047 A 20060223
DOCDB simple family (application)
US 0316734 W 20030528; AU 2003240810 A 20030528; BR 0311362 A 20030528; CA 2487858 A 20030528; CN 03817331 A 20030528; EP 03731406 A 20030528; JP 2004508268 A 20030528