Global Patent Index - EP 1509614 A4

EP 1509614 A4 20070912 - MAP-KINASE INHIBITORS AS REGULATORS OF TUMOR-ASSOCIATED ANTIGEN EXPRESSION

Title (en)

MAP-KINASE INHIBITORS AS REGULATORS OF TUMOR-ASSOCIATED ANTIGEN EXPRESSION

Title (de)

MAP-KINASE INHIBITOREN ZUR REGULIERUNG VON TUMORASSOZIIERTEN ANTIGENE EXPRESSION

Title (fr)

INHIBITEURS DE LA PROTEINE KINASE ASSOCIEE AUX MEMBRANES EN TANT QUE REGULATEURS DE L'EXPRESSION DE L'ANTIGENE SPECIFIQUE DE TUMEURS

Publication

EP 1509614 A4 20070912 (EN)

Application

EP 03717900 A 20030218

Priority

  • US 0304786 W 20030218
  • US 35758602 P 20020215

Abstract (en)

[origin: WO2004087941A1] This invention relates to methods for identifying agents that modulate expression of tumor-associated antigens in tumor cells. The invention also relates to agents and pharmaceutical compositions containing such agents that modulate expression of tumor-associated antigens in tumor cells. The invention, therefore, is particularly useful, inter alia, for treating subjects with autologous, solid tumors having cells that express, or that can be induced to express, tumor-associated antigens. One category of materials according to the invention is tumor-antigen expression up-regulating agents. These agents include modulators of the MAPK/ERKL signaling cascade, and more specifically modulators of MEK1/2 and ERK1/2 activity.

IPC 1-7

C12Q 1/00; C12Q 1/68; A01N 43/04; A61K 39/00

IPC 8 full level

A01N 43/04 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); C12Q 1/00 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C12Q 1/6886 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01)

Citation (search report)

  • [PX] WO 0217952 A2 20020307 - ANDEL INST VAN [US], et al
  • [A] KURNICK J T ET AL: "A novel autocrine pathway of tumor escape from immune recognition: melanoma cell lines produce a soluble protein that diminishes expression of the gene encoding the melanocyte lineage melan-A/MART-1 antigen through down-modulation of its promoter.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 AUG 2001, vol. 167, no. 3, 1 August 2001 (2001-08-01), pages 1204 - 1211, XP002433087, ISSN: 0022-1767
  • [PX] KOO H-M ET AL: "Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 5, 5 March 2002 (2002-03-05), pages 3052 - 3057, XP002225753, ISSN: 0027-8424
  • [T] KONO MICHIHIRO ET AL: "Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression.", MOLECULAR CANCER RESEARCH : MCR OCT 2006, vol. 4, no. 10, October 2006 (2006-10-01), pages 779 - 792, XP002433088, ISSN: 1541-7786
  • See references of WO 2004087941A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

DOCDB simple family (publication)

WO 2004087941 A1 20041014; AU 2003222221 A1 20041025; CA 2475206 A1 20030815; EP 1509614 A1 20050302; EP 1509614 A4 20070912

DOCDB simple family (application)

US 0304786 W 20030218; AU 2003222221 A 20030218; CA 2475206 A 20030218; EP 03717900 A 20030218