EP 1513808 A2 20050316 - FLUORINATED CYCLIC AMIDES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS
Title (en)
FLUORINATED CYCLIC AMIDES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS
Title (de)
FLUORIERTE ZYKLISCHE AMIDE ALS DIPEPTIDYLPEPTIDASE-IV INHIBITOREN
Title (fr)
AMIDES CYCLIQUES FLUORES UTILISES COMME INHIBITEURS DE LA DIPEPTIDYL PEPTIDASE IV
Publication
Application
Priority
- IB 0302257 W 20030523
- US 38615702 P 20020604
Abstract (en)
[origin: WO03101958A2] The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, hyperglycemia, impaired glucose tolerance, metabolic syndrome (Syndrome X or insulin resistance syndrome), glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome, anxiety, depression, insomnia, chronic fatigue, epilepsy, eating disorders, chronic pain, alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of identifying an insulin secretagogue agent for diabetes.
IPC 1-7
C07D 207/08; C07D 205/04; C07D 211/38; A61K 31/40; A61K 31/397; A61K 31/445; A61P 3/10; C12Q 1/37
IPC 8 full level
G01N 33/50 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/445 (2006.01); A61K 45/00 (2006.01); A61P 1/04 (2006.01); A61P 1/14 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 3/12 (2006.01); A61P 5/50 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 13/12 (2006.01); A61P 15/08 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/32 (2006.01); A61P 27/02 (2006.01); A61P 27/12 (2006.01); A61P 43/00 (2006.01); C07D 205/04 (2006.01); C07D 207/08 (2006.01); C07D 207/10 (2006.01); C07D 211/38 (2006.01); G01N 33/15 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 1/14 (2017.12); A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 3/12 (2017.12); A61P 5/50 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 13/12 (2017.12); A61P 15/08 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/08 (2017.12); A61P 25/20 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/32 (2017.12); A61P 27/02 (2017.12); A61P 27/12 (2017.12); A61P 43/00 (2017.12); C07D 205/04 (2013.01); C07D 207/08 (2013.01); C07D 211/38 (2013.01)
Citation (search report)
See references of WO 03101958A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03101958 A2 20031211; WO 03101958 A3 20040422; AU 2003232405 A1 20031219; AU 2003232405 A8 20031219; BR 0311608 A 20050222; CA 2487636 A1 20031211; EP 1513808 A2 20050316; JP 2005533771 A 20051110; MX PA04011958 A 20050331
DOCDB simple family (application)
IB 0302257 W 20030523; AU 2003232405 A 20030523; BR 0311608 A 20030523; CA 2487636 A 20030523; EP 03756085 A 20030523; JP 2004509652 A 20030523; MX PA04011958 A 20030523