EP 1514118 A2 20050316 - DIAGNOSTIC AND THERAPEUTIC USE OF RAS-GTPASE-ACTIVATING SH3-DOMAIN-BINDING PROTEIN 2 (G3BP2) FOR NEURODEGENERATIVE DISEASES
Title (en)
DIAGNOSTIC AND THERAPEUTIC USE OF RAS-GTPASE-ACTIVATING SH3-DOMAIN-BINDING PROTEIN 2 (G3BP2) FOR NEURODEGENERATIVE DISEASES
Title (de)
DIAGNOSTISCHE UND THERAPEUTISCHE VERWENDUNG VON RAS-GTPASE-AKTIVIERENDEM SH3-BINDENDEM PROTEIN 2 (G3BP2) FÜR NEURODEGENERATIVE ERKRANKUNGEN
Title (fr)
UTILISATION, EN MATIERE DE DIAGNOSTIC ET DE THERAPIE DE MALADIES NEURODEGENERATIVES, DE LA PROTEINE 2 (G3BP2) SE FIXANT AU DOMAINE SH3 DE LA PROTEINE ACTIVANT LA RAS GTPASE
Publication
Application
Priority
- EP 03740295 A 20030620
- EP 0306521 W 20030620
- EP 02013692 A 20020620
- US 38992702 P 20020620
Abstract (en)
[origin: WO2004001422A2] The present invention discloses the differential expression of the G3BP2 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the G3BP2 gene and its corresponding gene products. A method of screening for modulating agents of neuro-degenerative diseases is also disclosed.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12N 15/00 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C07K 14/4711 (2013.01); G01N 33/6896 (2013.01); A01K 2217/05 (2013.01); G01N 2800/2821 (2013.01)
Citation (search report)
See references of WO 2004001422A2
Citation (examination)
SCHNEIDER MARTIN: "A rational approach to maximize success rate in target discovery", ARCHIV DER PHARMAZIE, vol. 337, no. 12, 1 December 2004 (2004-12-01), Weinheim, pages 625-633, XP002553686, DOI: doi:10.1002/ardp.200400913
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004001422 A2 20031231; WO 2004001422 A3 20040318; AU 2003278497 A1 20040106; AU 2003278497 A8 20040106; EP 1514118 A2 20050316
DOCDB simple family (application)
EP 0306521 W 20030620; AU 2003278497 A 20030620; EP 03740295 A 20030620