Global Patent Index - EP 1515748 A4

EP 1515748 A4 20060412 - ANTI-ESTROGEN AND IMMUNE MODULATOR COMBINATIONS FOR TREATING BREAST CANCER

Title (en)

ANTI-ESTROGEN AND IMMUNE MODULATOR COMBINATIONS FOR TREATING BREAST CANCER

Title (de)

ANTIÖSTROGEN UND IMMUNMODULATOR-KOMBINATIONEN ZUR BEHANDLUNG VON BRUSTKREBS

Title (fr)

COMBINAISONS D'ANTIOESTROGENES ET D'IMMUNOMUDULATEURS POUR TRAITER LE CANCER DU SEIN

Publication

EP 1515748 A4 20060412 (EN)

Application

EP 02793936 A 20021113

Priority

  • US 0236633 W 20021113
  • US 33280101 P 20011114

Abstract (en)

[origin: WO03041654A2] Compositions for treating cancers of mucosal tissues including breast, prostate, ovary, colon are disclosed which include various combinations of new or conventional anti-estrogen compounds, aromatase inhibitors, immune modulators, immune inhibitors, immune inhibitor mimicking compounds and steroid or thyroid hormones. Methods of predicting susceptibility of a cancer of mucosal origin to treatment with a composition containing an immune inhibitor or an immune inhibitor mimicking compound are also disclosed. Preferred methods include identifying in a specimen of cancer cells the presence of a Poly-Ig (Fc) receptor or Poly-Ig-like (Fc) receptor capable of binding to an immune inhibitor or an immune inhibitor mimicking compound and of mediating immune inhibition of cancer cell growth.

IPC 1-7

A61K 39/395; G01N 33/53

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/138 (2006.01); A61K 31/429 (2006.01); A61K 31/4745 (2006.01); A61K 31/5685 (2006.01); A61K 35/74 (2006.01); A61K 45/06 (2006.01); G01N 33/574 (2006.01)

CPC (source: EP)

A61K 31/00 (2013.01); A61K 31/138 (2013.01); A61K 31/429 (2013.01); A61K 31/4745 (2013.01); A61K 31/5685 (2013.01); A61K 38/1774 (2013.01); A61K 45/06 (2013.01); G01N 33/574 (2013.01); G01N 33/57415 (2013.01); A61K 48/00 (2013.01); G01N 2333/70503 (2013.01)

Citation (search report)

  • [E] EP 1366366 A2 20031203 - SIRBASKU DAVID A [US]
  • [X] US 4919937 A 19900424 - MAUVAIS-JARVIS PIERRE [FR], et al
  • [X] US 4859585 A 19890822 - SONNENSCHEIN CARLOS [US], et al
  • [X] BRODIE A ET AL: "Aromatase inhibitors and their antitumor effects in model systems.", ENDOCRINE-RELATED CANCER. JUN 1999, vol. 6, no. 2, June 1999 (1999-06-01), pages 205 - 210, XP002367011, ISSN: 1351-0088
  • [X] ROSSO R ET AL: "ADJUVANT SYSTEMIC TREATMENT OF RESECTABLE BREAST CANCER ELEVEN YEARS RESULTS OF A MONOINSTITUTIONAL CHEMO-HORMONE-IMMUNOTHERAPY TRIAL", ANTICANCER RESEARCH, vol. 9, no. 4, 1989, pages 1153 - 1156, XP008057015, ISSN: 0250-7005
  • [X] SAWAI K ET AL: "CHEMO-ENDOCRINE-IMMUNOTHERAPY WITH ADRIAMYCIN TAMOXIFEN AND OK-432 PICIBANIL FOR ADVANCED BREAST CANCER", JOURNAL OF JAPAN SOCIETY FOR CANCER THERAPY, vol. 19, no. 6, 1984, pages 1315 - 1320, XP008057016, ISSN: 0021-4671
  • [X] MCCORMICK DAVID L ET AL: "Exceptional chemopreventive activity of low-dose dehydroepiandrosterone in the rat mammary gland", CANCER RESEARCH, vol. 56, no. 8, 1996, pages 1724 - 1726, XP008057031, ISSN: 0008-5472
  • [DX] SAVAGE P ET AL: "A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily", BRITISH JOURNAL OF CANCER, vol. 74, no. 9, 1996, pages 1482 - 1486, XP002073161, ISSN: 0007-0920
  • See references of WO 03041654A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

DOCDB simple family (publication)

WO 03041654 A2 20030522; WO 03041654 A3 20050106; AU 2002359401 A1 20030526; EP 1515748 A2 20050323; EP 1515748 A4 20060412

DOCDB simple family (application)

US 0236633 W 20021113; AU 2002359401 A 20021113; EP 02793936 A 20021113