EP 1516190 A1 20050323 - METHOD FOR IDENTIFYING AGONISTS OR ANTAGONISTS FOR THE G-PROTEIN COUPLED MAS-LIKE 1 RECEPTOR
Title (en)
METHOD FOR IDENTIFYING AGONISTS OR ANTAGONISTS FOR THE G-PROTEIN COUPLED MAS-LIKE 1 RECEPTOR
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG VON AGONISTEN ODER ANTAGONISTEN FÜR DEN G PROTEIN GEKOPPELTEN REZEPTOR "MAS LIKE 1"
Title (fr)
PROCEDE POUR IDENTIFIER DES AGONISTES OU DES ANTAGONISTES DU RECEPTEUR MAS DE TYPE 1 COUPLE A LA PROTEINE G
Publication
Application
Priority
- DE 10225443 A 20020608
- EP 0305601 W 20030528
Abstract (en)
[origin: DE10225443A1] Identifying a compound (I) that binds specifically to the G protein-coupled receptor mas-like-1 (R) by (i) treating at least one cell that expresses R on its surface (or a preparation of the cells that contains R) with at least one test compound and (ii) detecting any binding to R. Independent claims are also included for the following: (1) similar methods for identifying compounds that bind specifically to R and are competitive with respect to a first compound, or that bind specifically to R and either activate or inhibit it; (2) pharmaceutical composition containing compounds identified by the new methods; (3) use of substance P (or its cleavage products) or neuropeptide FF (a) for treating diseases associated with defects in R or (b) for preparing a complex with R; and (4) protein that comprises R to which substance P (or its cleavage products) or neuropeptide FF is bound specifically.
IPC 1-7
IPC 8 full level
A61K 38/08 (2019.01); A61K 38/17 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61P 9/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/567 (2006.01); G01N 33/74 (2006.01); A61K 38/095 (2019.01)
CPC (source: EP US)
A61K 38/046 (2013.01 - EP US); A61K 38/08 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 9/08 (2017.12 - EP); G01N 33/5008 (2013.01 - EP US); G01N 33/5041 (2013.01 - EP US); G01N 33/74 (2013.01 - EP US); A61K 38/095 (2018.12 - EP US); G01N 2333/726 (2013.01 - EP US); G01N 2500/00 (2013.01 - EP US); G01N 2500/10 (2013.01 - EP US)
Citation (search report)
See references of WO 03104818A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 10225443 A1 20031218; AT E542141 T1 20120215; AU 2003237702 A1 20031222; CA 2489083 A1 20031218; EP 1516190 A1 20050323; JP 2005528923 A 20050929; JP 4359238 B2 20091104; US 2004029180 A1 20040212; US 2007259378 A1 20071108; US 7794927 B2 20100914; WO 03104818 A1 20031218
DOCDB simple family (application)
DE 10225443 A 20020608; AT 03735480 T 20030528; AU 2003237702 A 20030528; CA 2489083 A 20030528; EP 0305601 W 20030528; EP 03735480 A 20030528; JP 2004511838 A 20030528; US 45670003 A 20030606; US 55621606 A 20061103