EP 1517702 A2 20050330 - IMMUNOGENIC HBc CHIMER PARTICLES STABILIZED WITH AN N-TERMINAL CYSTEINE
Title (en)
IMMUNOGENIC HBc CHIMER PARTICLES STABILIZED WITH AN N-TERMINAL CYSTEINE
Title (de)
MIT EINEM N-TERMINALEN CYSTEIN STABILISIERTE IMMUNOGENE HBc-CHIMÄRE-PARTIKEL
Title (fr)
PARTICULES CHIMERIQUES HBC IMMUNOGENES STABILISEES AVEC UNE CYSTEINE D'EXTREMITE N-TERMNALE
Publication
Application
Priority
- US 0305196 W 20030221
- US 8029902 A 20020221
- US 8201402 A 20020221
- US 27461602 A 20021021
Abstract (en)
[origin: WO03102165A2] A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that is engineered for both enhanced stability of self-assembled particles and the display of an immunogenic B cell or T cell epitope, or both, such as a B cell epitope polypeptide of the influenza M2 protein and a T cell epitope of the influenza NP protein. An immunogenic epitope is peptide-bonded to one or more of the N-terminus, in the immunogenic loop or at the C-terminus of HBc, whereas the enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near the amino-terminus of the chimer molecule. Methods of making and using the chimers are also disclosed.
IPC 1-7
IPC 8 full level
A61K 39/015 (2006.01); A61K 39/145 (2006.01); A61K 39/29 (2006.01); A61K 39/385 (2006.01); C07K 14/02 (2006.01); C12Q 1/70 (2006.01)
CPC (source: EP)
A61K 39/015 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); C07K 14/005 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/543 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/57 (2013.01); C07K 2319/00 (2013.01); C12N 2730/10122 (2013.01); C12N 2730/10134 (2013.01); C12N 2760/16134 (2013.01); Y02A 50/30 (2017.12)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03102165 A2 20031211; WO 03102165 A3 20050106; AU 2003213168 A1 20031219; AU 2003213168 A8 20031219; EP 1517702 A2 20050330; EP 1517702 A4 20060503
DOCDB simple family (application)
US 0305196 W 20030221; AU 2003213168 A 20030221; EP 03709214 A 20030221