EP 1517896 A2 20050330 - PHENYL- AND PYRIDYL-DIAZAHETEROCYCLES HAVING A TNF-MODULATING ACTIVITY
Title (en)
PHENYL- AND PYRIDYL-DIAZAHETEROCYCLES HAVING A TNF-MODULATING ACTIVITY
Title (de)
PHENYL- UND PYRIDYL-DIAZAHETEROCYCLEN MIT EINER TNF MODULIERENDEN WIRKUNG
Title (fr)
PHENYL- ET PYRIDYL-DIAZAHETEROCYCLES AYANT UNE ACTIVITE MODULATRICE DU TNF
Publication
Application
Priority
- FR 0301813 W 20030616
- FR 0207507 A 20020618
Abstract (en)
[origin: FR2840896A1] N-((Iso)quinolyl-alkyl)-N'-(phenyl or pyridyl)-diaza-heterocyclic compounds (I) are new. Diaza-heterocyclic compounds of formula (I) and their salts and solvates are new. X = N or CH; R1 = H, halo or CF3; R2, R3 = H or Me; n = 0 or 1; W = piperazine-1,4-diyl, 3,8-diaza-bicyclo-(3.2.1)-octane-3,8-diyl (bonded in either orientation) or homopiperazine-1,4-diyl (all optionally in mono- or di-N-oxide form); A = 6- or 7-(iso)quinolyl group of formula (a) or (b) (both optionally in N-oxide form); R4 = H, halo, 1-4C alkyl, CF3, NH2 or mono- or di-(1-4C alkyl)-amino; R5 = H, halo, 1-4C alkoxy, 1-4C alkyl or CF3; and R6 = H, 1-4C alkoxy or 1-4C alkyl. Independent claims are also included for: (1) Preparation of (I); and (2) New trifluoromethyl-benzene or -pyridine derivative intermediates of formula (II'). W' = 3,8-diaza-bicyclo-(3.2.1)-octane-3,8-diyl (bonded in either orientation).
IPC 1-7
C07D 217/02; C07D 215/04; C07D 487/08; C07D 401/12; C07D 401/06; A61K 31/4709; A61K 31/4725; A61P 9/00; A61P 29/00
IPC 8 full level
A61K 31/497 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61P 1/04 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 19/02 (2006.01); A61P 19/06 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 25/04 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/06 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 33/06 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07D 215/04 (2006.01); C07D 217/02 (2006.01); C07D 241/08 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP US)
A61P 1/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/06 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/06 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 33/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 215/04 (2013.01 - EP US); C07D 217/02 (2013.01 - EP US); C07D 241/08 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US)
Citation (search report)
See references of WO 03106425A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2840896 A1 20031219; FR 2840896 B1 20050408; AU 2003263237 A1 20031231; AU 2003263237 A8 20031231; EP 1517896 A2 20050330; JP 2005533790 A 20051110; US 2005209216 A1 20050922; WO 03106425 A2 20031224; WO 03106425 A3 20040401
DOCDB simple family (application)
FR 0207507 A 20020618; AU 2003263237 A 20030616; EP 03760042 A 20030616; FR 0301813 W 20030616; JP 2004513258 A 20030616; US 51865205 A 20050225