EP 1522340 A1 20050413 - Beads with immobilized amphiphilic molecules, method of fabrication thereof, and method of arraying beads for capillary beads-array
Title (en)
Beads with immobilized amphiphilic molecules, method of fabrication thereof, and method of arraying beads for capillary beads-array
Title (de)
Kügelchen mit immobilisierten amphiphilen Molekülen, Verfahren zu deren Herstellung und Verfahren zur Herstellung einer Kapillarkügelchenanordnung
Title (fr)
Billes comprenant des molécules amphiphiles immobilisées, méthode pour leur préparation et méthode pour mettre en place un réseau de billes capillaires
Publication
Application
Priority
JP 2003349818 A 20031008
Abstract (en)
A capillary beads-array attractive to users is provided by immobilizing amphiphilic molecules on the surface of beads (212) in uniform orientation and arraying the beads in a capillary formed on a soft resin. A monomolecular layer of the amphiphilic molecules is formed on the bead surface (212) by putting beads having hydrophilic portions on the surface in water phase, dropping amphiphilic molecules containing a hydrophilic portion and a hydrophobic portion onto the water phase, pouring an oil lighter than water to form a monomolecular film of the amphiphilic molecules at an oil/water interface (205), capturing a single bead with the tip of a bead picker (211), lifting up the tip of the bead picker (211) to allow the bead (212) to reach the oil/water interface (205), and allowing to form a covalent bond between a functional group in the hydrophilic portion on the bead surface (212) and a functional group in the hydrophilic portion of the amphiphilic molecules. <IMAGE>
IPC 1-7
IPC 8 full level
B01J 19/00 (2006.01); G01N 33/53 (2006.01); G01N 37/00 (2006.01); B05D 1/20 (2006.01)
CPC (source: EP US)
B01J 19/0046 (2013.01 - EP US); B82Y 30/00 (2013.01 - EP US); B01J 2219/00468 (2013.01 - EP US); B01J 2219/005 (2013.01 - EP US); B01J 2219/00576 (2013.01 - EP US); B01J 2219/00585 (2013.01 - EP US); B01J 2219/00596 (2013.01 - EP US); B01J 2219/00646 (2013.01 - EP US); B01J 2219/00657 (2013.01 - EP US); B01J 2219/00677 (2013.01 - EP US); B01J 2219/0072 (2013.01 - EP US); B05D 1/202 (2013.01 - EP US)
Citation (search report)
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- [XY] WO 9820019 A1 19980514 - SEQUENOM INC [US], et al
- [XY] WO 9602830 A1 19960201 - TECHNOBIOCHIP [IT], et al
- [Y] WO 0061198 A1 20001019 - HITACHI CHEMICAL CO LTD [JP], et al
- [X] US 2003180472 A1 20030925 - ZHOU OTTO [US], et al
- [XY] ROBERT J. HUNTER: "Foundations of Colloid Science", 1992, OXFORD UNIVERSITY PRESS, XP002314216
- [X] ELVERS B ET AL: "ULLMANN'S ENCYCLOPEDIA OF INDUSTRIAL CHEMISTRY, 1.5. THIN FILMS BY ADSORPTION PROCESSES", ULLMANN'S ENCYCLOPEDIA OF INDUSTRIAL CHEMISTRY. SURGICAL MATERIALS TO THIOUREA, WEINHEIM, VCH, DE, vol. VOL. A26, 1995, pages 696 - 706, XP002228609, ISBN: 3-527-20126-2
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
EP 1522340 A1 20050413; JP 2005114576 A 20050428; US 2005079552 A1 20050414
DOCDB simple family (application)
EP 04020803 A 20040901; JP 2003349818 A 20031008; US 92834504 A 20040830