EP 1524969 A2 20050427 - MICROCAPSULES WITH MODIFIED RELEASE OF ACTIVE PRINCIPLES WITH LOW SOLUBILITY FOR ORAL DELIVERY
Title (en)
MICROCAPSULES WITH MODIFIED RELEASE OF ACTIVE PRINCIPLES WITH LOW SOLUBILITY FOR ORAL DELIVERY
Title (de)
MIKROKAPSELN MIT GESTEUERTER VERABREICHUNG VON SCHWERLÖSLICHEN WIRKSTOFFEN ZUR ORALEN ANWENDUNG
Title (fr)
MICROCAPSULES A LIBERATION MODIFIEE DE PRINCIPES ACTIFS PEU SOLUBLES POUR ADMINISTRATION PER OS
Publication
Application
Priority
- FR 0302384 W 20030728
- FR 0209530 A 20020726
Abstract (en)
[origin: WO2004010984A2] The invention concerns microcapsules for reliably modified release and adapted to industrial reproduction of an active principle hardly water-soluble, other than anti-hyperglycemia agents Each of said microcapsules comprises a core of hardly soluble active principle and a coating film applied on the core. Their mean diameter is less than 1000 microns. The coating film contains a film-forming polymer (P1) insoluble in gastrointestinal tract fluids, a water-soluble polymer (P2), a plasticizer (PL), and optionally a lubricating surfactant (TA). Said coating film represents at least 4 % p/p of dry matter of their total weight, and its components P1, P2, PL satisfy the following characteristics: dry weight mass fraction of P1 relative to the total coating weight ranging between 40 and 90 %; dry matter weight fraction of PL/P1+P2 ranging between 15 and 60 %; dry matter weight fraction of PL/P1+PL ranging between 1 and 30 %. The invention also concerns the uses of said microcapsules in galenic formulation.
IPC 1-7
IPC 8 full level
A61K 9/10 (2006.01); A61K 9/14 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61K 31/43 (2006.01); A61K 31/522 (2006.01); A61K 47/12 (2006.01); A61K 47/14 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2006.01); A61K 47/38 (2006.01); A61K 47/44 (2006.01)
CPC (source: EP KR US)
A61K 9/50 (2013.01 - KR); A61K 9/5015 (2013.01 - EP US); A61K 9/5026 (2013.01 - EP US); A61K 9/5047 (2013.01 - EP US)
Citation (search report)
See references of WO 2004010984A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2842735 A1 20040130; FR 2842735 B1 20060106; AU 2003269068 A1 20040216; AU 2003269068 B2 20090122; BR 0312988 A 20050621; CA 2493464 A1 20040205; CA 2493464 C 20120703; CN 1681483 A 20051012; CN 1681483 B 20111228; EP 1524969 A2 20050427; EP 2272506 A2 20110112; EP 2272506 A3 20130710; IL 166431 A0 20060115; JP 2005535680 A 20051124; KR 20050026518 A 20050315; MX PA05001076 A 20050606; US 2006275376 A1 20061207; US 2007160678 A1 20070712; US 8821935 B2 20140902; WO 2004010984 A2 20040205; WO 2004010984 A3 20040408; ZA 200500734 B 20060329
DOCDB simple family (application)
FR 0209530 A 20020726; AU 2003269068 A 20030728; BR 0312988 A 20030728; CA 2493464 A 20030728; CN 03821296 A 20030728; EP 03750853 A 20030728; EP 10184459 A 20030728; FR 0302384 W 20030728; IL 16643105 A 20050120; JP 2004523895 A 20030728; KR 20057001414 A 20050126; MX PA05001076 A 20030728; US 52223403 A 20030728; US 58394006 A 20061020; ZA 200500734 A 20060125