EP 1531878 A1 20050525 - ENHANCED PHOSPHOLIPID REDUCTION AND CALCIFICATION MITIGATION OF BIOLOGICAL MATERIALS
Title (en)
ENHANCED PHOSPHOLIPID REDUCTION AND CALCIFICATION MITIGATION OF BIOLOGICAL MATERIALS
Title (de)
VERBESSERTE PHOSPHOLIPID-REDUKTION UND VERRINGERUNG DER KALZIFIZIERUNG VON BIOLOGISCHEN MATERIALIEN
Title (fr)
ATTENUATION RENFORCEE DE LA CALCIFICATION DE MATERIAUX BIOLOGIQUES ET REDUCTION ACCRUE DE LEUR TENEUR EN PHOSPHOLIPIDES
Publication
Application
Priority
- US 0322121 W 20030716
- US 39687902 P 20020716
Abstract (en)
[origin: WO2004006974A1] There is a need in the tissue treatment arts of methods for effectively mitigating calcification, reducing calcification and reducing phospholipid content of implanted bioprosthetic tissues. The invention provides an effective protocol for preparing biological tissue for incorporation as a bioprosthetic device. Disclosed herein is the discovery that calcification of biological tissue is mitigated and phospholipid content is reduced by including a step in the pre-implantation protocol whereby the biological tissue is treated with a surfactant and cross linking agent in the absence of a denaturant. Furthermore, the biological tissues prepared under this protocol are well suited for use in bioprosthetic devices.
IPC 1-7
IPC 8 full level
A61L 27/00 (2006.01); A61L 27/36 (2006.01); A61L 27/50 (2006.01); A61L 31/00 (2006.01); A61L 31/14 (2006.01)
CPC (source: EP US)
A61L 27/18 (2013.01 - EP US); A61L 27/3687 (2013.01 - EP US); A61L 27/505 (2013.01 - EP US); A61L 31/005 (2013.01 - EP US); A61L 31/143 (2013.01 - EP US); A61L 2400/02 (2013.01 - EP US)
Citation (search report)
See references of WO 2004006974A1
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 2004006974 A1 20040122; AU 2003249272 A1 20040202; BR 0305562 A 20040928; CA 2490060 A1 20040122; EP 1531878 A1 20050525; JP 2005532877 A 20051104; US 2004093674 A1 20040520
DOCDB simple family (application)
US 0322121 W 20030716; AU 2003249272 A 20030716; BR 0305562 A 20030716; CA 2490060 A 20030716; EP 03764694 A 20030716; JP 2004521862 A 20030716; US 62071203 A 20030716