EP 1532140 A1 20050525 - THIENYLHYDRAZON WITH DIGITALIS-LIKE PROPERTIES ( POSITIVE INOTROPIC EFFECTS )
Title (en)
THIENYLHYDRAZON WITH DIGITALIS-LIKE PROPERTIES ( POSITIVE INOTROPIC EFFECTS )
Title (de)
THIENYLHYDRAZONE MIT DIGITALIS-ANALOGEN EIGENSCHAFTEN ( POSITIV INOTROPER EFFEKT )
Title (fr)
THIENYLHYDRAZONE POSSEDANT DES PROPRIETES ANALOGUES A CELLES DE LA DIGITALE (EFFETS INOTROPES POSITIFS)
Publication
Application
Priority
- US 0017024 W 20000621
- US 14035299 P 19990621
Abstract (en)
[origin: WO0078754A1] The invention discloses a compound having the formula (I) wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, unsubstituted phenyl, and substituted phenyl; R2 is selected from the group consisting of H, alkene, un-substituted phenol, and substituted phenyl; and pharmaceutically acceptable salts thereof, having digitalis-like properties. The invention further discloses a novel method to synthesize 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294). LASSBio-294 produces positive inotropic effect on cardiac and skeletal muscle. The invention is useful for the treatment of congestive heart failure and muscle fatigue. It lacks toxic effects seen in digitalis glycosides.
IPC 1-7
IPC 8 full level
A61P 9/04 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP)
A61P 9/04 (2017.12); C07D 409/12 (2013.01)
Citation (search report)
See references of WO 0078754A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL
DOCDB simple family (publication)
WO 0078754 A1 20001228; AU 5628700 A 20010109; CA 2384525 A1 20001228; CA 2384525 C 20070306; EP 1532140 A1 20050525
DOCDB simple family (application)
US 0017024 W 20000621; AU 5628700 A 20000621; CA 2384525 A 20000621; EP 00941596 A 20000621