EP 1532244 A4 20051214 - NOVEL HUMAN HISTONE DEACETYLASES
Title (en)
NOVEL HUMAN HISTONE DEACETYLASES
Title (de)
NEUE HUMANE HISTON-DEACETYLASEN
Title (fr)
NOUVELLES HISTONES DEACETYLASES HUMAINES
Publication
Application
Priority
- US 0219560 W 20020614
- US 29829601 P 20010614
Abstract (en)
[origin: WO02102323A2] The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.
IPC 1-7
IPC 8 full level
C12N 9/16 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); C12N 9/16 (2013.01 - EP US)
Citation (search report)
- [E] WO 03029451 A2 20030410 - CANCER RES INST [GB], et al
- [X] ZHOU XIANBO ET AL: "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 97, no. 3, 1 February 2000 (2000-02-01), pages 1056 - 1061, XP002341184, ISSN: 0027-8424
- [X] DATABASE EMBL [online] 17 November 1998 (1998-11-17), "Homo sapiens histone deacetylase HDAC7 mRNA, partial cds.", XP002349999, retrieved from EBI accession no. AF124924 Database accession no. AF124924
- [A] WEIDLE U H ET AL: "INHIBITION OF HISTONE DEACETYLASES: A NEW STRATEGY TO TARGET EPIGENETIC MODIFICATIONS FOR ANTICANCER TREATMENT", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 20, May 2000 (2000-05-01), pages 1471 - 1485, XP001098720, ISSN: 0250-7005
- [A] CRESS W D ET AL: "HISTONE DEACETYLASES, TRANSCRIPTIONAL CONTROL, AND CANCER", JOURNAL OF CELLULAR PHYSIOLOGY, LISS, NEW YORK, NY, US, vol. 184, no. 1, July 2000 (2000-07-01), pages 1 - 16, XP008010186, ISSN: 0021-9541
- [A] YAN L YANG X DAVIDSON N E: "Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer", JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, PLENUM PRESS, NEW YORK, NY,, US, vol. 6, no. 2, April 2001 (2001-04-01), pages 183 - 192, XP002955249, ISSN: 1083-3021
- [PA] PETRIE K R ET AL: "ROLE OF A NOVEL CLASS II HISTONE DEACETYLASE IN NORMAL AND LEUKEMIA-ASSOCIATED TRANSCRIPTIONAL REPRESSION", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 98, no. 11, PART 1, 16 November 2001 (2001-11-16), pages 568A, XP008015437, ISSN: 0006-4971
- See references of WO 02102323A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02102323 A2 20021227; WO 02102323 A3 20050331; AU 2002318364 A1 20030102; CA 2450129 A1 20021227; EP 1532244 A2 20050525; EP 1532244 A4 20051214; US 2003161830 A1 20030828; US 2006269559 A1 20061130; US 7199227 B2 20070403; US 7521044 B2 20090421
DOCDB simple family (application)
US 0219560 W 20020614; AU 2002318364 A 20020614; CA 2450129 A 20020614; EP 02747919 A 20020614; US 17209402 A 20020614; US 49720506 A 20060801