EP 1534837 A4 20060920 - APICOMPLEXAN PATHWAYS, INHIBITIORS, AND DRUG DELIVERY
Title (en)
APICOMPLEXAN PATHWAYS, INHIBITIORS, AND DRUG DELIVERY
Title (de)
APICOMPLEXAN-WEGE, INHIBITOREN UND WIRKSTOFFZUF HRUNG
Title (fr)
VOIES D'APICOMPLEXAN, INHIBITEURS ET ADMINISTRATION DE MEDICAMENTS
Publication
Application
Priority
- US 0325571 W 20030814
- US 40403302 P 20020815
- US 43820503 P 20030106
- US 46343203 P 20030416
- US 47288703 P 20030523
Abstract (en)
[origin: WO2004016220A2] An apicomplexan Fab I gene and the gene for DAHP synthase in Toxoplasma gondii, and their encoded enzymes, provide means to rationally design novel inhibitory compositions useful for prevention and treatment of apicomplexan related diseases. For example, triclosan is a lead compound. Delivery of inhibitors to microorganisms by short amino acid polymers demonstrates a novel method to treat active infections, and demonstrates a new approach for delivering antimicrobials to encysted, latent parasites. The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. Because it is absent in mammals, it is an appealing therapeutic target. Genes encoding the shikimate pathway enzymes in T. gondii are described. Putative AOX sequences were identified and sequenced from both type 1 and type 2 strains of C. parvum. The gene encodes a polypeptide of 336 amino acids and has a predicted N-terminal transit sequence similar to that found in proteins targeted to the mitochondria of other species. Alternative oxidase (AOX) is another target for new anti-microbial agents for C. parvum.
IPC 8 full level
C12N 15/31 (2006.01); A61K 39/012 (2006.01); A61K 47/48 (2006.01); C07H 21/04 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/02 (2006.01); C12N 9/88 (2006.01); C12N 15/12 (2006.01); C12N 15/63 (2006.01); C12P 21/06 (2006.01); C12Q 1/18 (2006.01)
CPC (source: EP)
C12N 9/001 (2013.01); C12N 9/88 (2013.01); C12Q 1/18 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
- [X] WO 0249576 A2 20020627 - MCLEOD RIMA [US], et al
- [XY] WO 0127262 A1 20010419 - PANTHECO AS [DK], et al
- [Y] WO 9852614 A2 19981126 - UNIV LELAND STANFORD JUNIOR [US], et al
- [X] MCLEOD R ET AL: "TRICLOSAN INHIBITS THE GROWTH OF PLASMODIUM FALCIPARUM AND TOXOPLASMA GONDII BY INHIBITION OF APICOMPLEXAN FAB I", INTERNATIONAL JOURNAL OF PARASITOLOGY, PERGAMON PRESS, GB, vol. 31, no. 2, 2001, pages 109 - 113, XP001205626, ISSN: 0020-7519
- [A] ZUTHER E ET AL: "GROWTH OF TOXOPLASMA GONDII IS INHIBITED BY ARYLOXYPHENOXYPROPIONATE HERBICIDES TARGETING ACETYL-COA CARBOXYLASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 96, no. 23, 9 November 1999 (1999-11-09), pages 13387 - 13392, XP000952826, ISSN: 0027-8424
- [T] SAMUEL B U ET AL: "DELIVERY OF ANTIMICROBIALS INTO PARASITES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 24, SUPPL 2, 25 November 2003 (2003-11-25), pages 14281 - 14286, XP009045693, ISSN: 0027-8424
- See references of WO 2004016220A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004016220 A2 20040226; WO 2004016220 A3 20050224; AU 2003259848 A1 20040303; CA 2535760 A1 20040226; EP 1534837 A2 20050601; EP 1534837 A4 20060920
DOCDB simple family (application)
US 0325571 W 20030814; AU 2003259848 A 20030814; CA 2535760 A 20030814; EP 03788516 A 20030814