EP 1537114 B8 20071003 - ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS
Title (en)
ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS
Title (de)
ORGANISCHE VERBINDUNGEN ALS MITTEL ZUR BEHANDLUNG VON ALDOSTERONBEDINGTEN ZUSTÄNDEN
Title (fr)
COMPOSES ORGANIQUES SERVANT D'AGENTS POUR LE TRAITEMENT D'ETATS PATHOLOGIQUES INDUITS PAR L'ALDOSTERONE
Publication
Application
Priority
- EP 0308720 W 20030806
- US 40169302 P 20020807
Abstract (en)
[origin: WO2004014914A1] Compounds of formula (I), provide pharmacological agents which are inhibitors of the P450 enzyme, aldosterone synthase, and thus may be employed for the treatment of aldosterone mediated conditions. Accordingly, the compounds of formula (I) may be employed for prevention, delay of progression, or treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post myocardial infarction, coronary heart diseases, increased formation of collagen, fibrosis, and remodeling following hypertension and endothelial dysfunction. Preferred are the compounds of formula (I) which are selective inhibitors of aldosterone synthase devoid of undesirable side effects due to general inhibition of cytochrome P450 enzymes.
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/5517 (2006.01); A61P 5/40 (2006.01); C07D 235/00 (2006.01); C07D 241/00 (2006.01); C07D 243/00 (2006.01)
CPC (source: EP US)
A61P 5/40 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/04 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 471/04 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004014914 A1 20040219; AT E335744 T1 20060915; AU 2003253387 A1 20040225; BR 0313293 A 20050614; CA 2494636 A1 20040219; CN 100404535 C 20080723; CN 1688583 A 20051026; CY 1106217 T1 20110608; DE 60307483 D1 20060921; DE 60307483 T2 20070705; DK 1537114 T3 20061113; EP 1537114 A1 20050608; EP 1537114 B1 20060809; EP 1537114 B8 20071003; ES 2270143 T3 20070401; HK 1080290 A1 20060421; JP 2006505520 A 20060216; JP 4533139 B2 20100901; PT 1537114 E 20061229; US 2006166973 A1 20060727; US 7732603 B2 20100608
DOCDB simple family (application)
EP 0308720 W 20030806; AT 03784194 T 20030806; AU 2003253387 A 20030806; BR 0313293 A 20030806; CA 2494636 A 20030806; CN 03823878 A 20030806; CY 061101527 T 20061024; DE 60307483 T 20030806; DK 03784194 T 20030806; EP 03784194 A 20030806; ES 03784194 T 20030806; HK 05111160 A 20051206; JP 2004526900 A 20030806; PT 03784194 T 20030806; US 52387005 A 20050318