Global Patent Index - EP 1537125 A1

EP 1537125 A1 20050608 - METHOD FOR THE ORGANOMETALLIC PRODUCTION OF ORGANIC INTERMEDIATE PRODUCTS COMPRISING CARBON-HETEROATOM BONDS ACHIEVED BY THE DEPROTONATION OF HETEROATOMS

Title (en)

METHOD FOR THE ORGANOMETALLIC PRODUCTION OF ORGANIC INTERMEDIATE PRODUCTS COMPRISING CARBON-HETEROATOM BONDS ACHIEVED BY THE DEPROTONATION OF HETEROATOMS

Title (de)

VERFAHREN ZUR METALLORGANISCHEN HERSTELLUNG ORGANISCHER ZWISCHENPRODUKTE MIT KOHLENSTOFF-HETEROATOM-BINDUNGEN BER DIE DEPROTONIERUNG VON HETEROATOMEN

Title (fr)

PROCEDE DE FABRICATION ORGANOMETALLIQUE DE PRODUITS INTERMEDIAIRES ORGANIQUES CONTENANT DES LIAISONS CARBONE-HETEROATOME PAR DEPROTONATION D'HETEROATOMES

Publication

EP 1537125 A1 20050608 (DE)

Application

EP 03794905 A 20030821

Priority

  • DE 10240260 A 20020831
  • EP 0309250 W 20030821

Abstract (en)

[origin: DE10240260A1] Formation of heteroatom-carbon bonds comprises reacting an aliphatic or aromatic halide with lithium, using the resulting organolithium compound to deprotonate a heteroatom, and reacting the resulting lithium salt with a carbon electrophile. Formation of heteroatom-carbon bonds comprises reacting an aliphatic or aromatic halide of formula (I) with lithium, using the resulting organolithium compound of formula (II) to deprotonate a compound of formula (III), and reacting the resulting lithium salt of formula (IV) with a carbon electrophile to give a product of formula (V): R-Hal (I) R-Li (II) R1-X-H (III) R1-X-Li (IV) R1-X-El (V) R = 1-20C alkyl, aryl or heteroaryl; alkyl substituted with alkyl, aryl, heteroaryl, alkoxy, dialkylamino or alkylthio; or (un)substituted 3-8C cycloalkyl; Hal = F, Cl, Br or I; X = O, S, =N or NR2; R1, R2 = H, 1-20C alkyl, 2-20C alkenyl or alkynyl, substituted (cyclo)alkyl, acyl, alkoxy, aryloxy, (di)alkylamino, (di)arylamino, imino, sulfone, sulfonyl, (un)substituted phenyl, alkylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, (di)alkyl- or (di)arylcarbamoyl, alkylarylcarbamoyl, alkoxyalkyl, carboxylate, alkylcarboxylate, CN, CHO or heteroaryl, or R1+R2 forms an aromatic or alicyclic ring; El = electrophile.

IPC 1-7

C07F 1/02; C07B 41/02; C07C 323/22; C07C 319/14

IPC 8 full level

C07B 41/00 (2006.01); C07B 43/00 (2006.01); C07B 61/00 (2006.01); C07C 249/16 (2006.01); C07C 269/04 (2006.01); C07C 271/28 (2006.01); C07C 281/04 (2006.01); C07C 303/40 (2006.01); C07C 311/53 (2006.01); C07C 319/14 (2006.01); C07C 321/14 (2006.01); C07D 307/42 (2006.01); C07C 251/86 (2006.01)

CPC (source: EP US)

C07B 41/00 (2013.01 - EP US); C07B 43/00 (2013.01 - EP US); C07C 249/16 (2013.01 - EP US); C07C 269/04 (2013.01 - EP US); C07C 303/40 (2013.01 - EP US); C07C 319/14 (2013.01 - EP US); C07D 307/42 (2013.01 - EP US)

C-Set (source: EP US)

  1. C07C 319/14 + C07C 321/14
  2. C07C 303/40 + C07C 311/53
  3. C07C 269/04 + C07C 271/28
  4. C07C 249/16 + C07C 251/86

Citation (search report)

See references of WO 2004024737A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

DE 10240260 A1 20040311; EP 1537125 A1 20050608; JP 2005537331 A 20051208; US 2005258553 A1 20051124; WO 2004024737 A1 20040325

DOCDB simple family (application)

DE 10240260 A 20020831; EP 0309250 W 20030821; EP 03794905 A 20030821; JP 2004535121 A 20030821; US 52632705 A 20050228