EP 1539111 A1 20050615 - ORAL DOSAGE FORMS OF WATER INSOLUBLE DRUGS AND METHODS OF MAKING THE SAME

Title (en)

ORAL DOSAGE FORMS OF WATER INSOLUBLE DRUGS AND METHODS OF MAKING THE SAME

Title (de)

ORALE DOSIERFORMEN VON WASSERUNL SLICHEN ARZNEIMITTELN UND HERSTELLUNGSVERFAHREN DAF R

Title (fr)

FORMES GALENIQUES ORALES DE MEDICAMENTS INSOLUBLES DANS L'EAU ET LEURS PROCEDE DE FABRICATION

Publication

EP 1539111 A1 20050615 (EN)

Application

EP 03766786 A 20030805

Priority

NL 0300563 W 20030805
US 40112102 P 20020805

Abstract (en)

[origin: WO2004012714A1] A method of making an oral dosage form of a water insoluble drug such as Saquinavir or Cyclosporine or Paclitaxel is carried out by: (a) providing a single phase working solution comprising or consisting essentially of an active agent, water, a water-soluble polymer, and a solvent, said solvent selected from the group consisting of alcohol, acetone, and mixtures thereof; and may or may not contain a surfactant and pH of the said working solution may or may not be adjusted (b) providing particles formed from a pharmaceutically acceptable core material; (c) combining, preferably by spraying, said working solution with said particles to produce active agent-coated particles; such drug loaded particles may contain an external coat (d) drying said active agent-coated particles; and (e) forming said dried particles into an oral dosage form. Dried particles produced by the process, oral dosage forms containing such particles, and methods of treatment therewith are also described.

IPC 1-7

A61K 9/16; A61K 9/50; A61K 9/28; A61K 31/00

IPC 8 full level

A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 31/00 (2006.01)

CPC (source: EP)

A61K 9/1676 (2013.01); A61K 9/5078 (2013.01); A61K 31/00 (2013.01)

Citation (search report)

See references of WO 2004012714A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004012714 A1 20040212; AU 2003256157 A1 20040223; EP 1539111 A1 20050615

DOCDB simple family (application)

NL 0300563 W 20030805; AU 2003256157 A 20030805; EP 03766786 A 20030805