Global Patent Index - EP 1539197 A4

EP 1539197 A4 20060802 - TREATMENT OF TUMOR CELLS FOR USE IN IMMUNOTHERAPY OF CANCER

Title (en)

TREATMENT OF TUMOR CELLS FOR USE IN IMMUNOTHERAPY OF CANCER

Title (de)

BEHANDLUNG VON TUMORZELLEN ZUR VERWENDUNG IN DER IMMUNTHERAPIE BEI KREBS

Title (fr)

TRAITEMENT DE CELLULES TUMORALES DESTINEES A L'IMMUNOTHERAPIE DU CANCER

Publication

EP 1539197 A4 20060802 (EN)

Application

EP 03710844 A 20030203

Priority

  • US 0303321 W 20030203
  • US 35409402 P 20020201

Abstract (en)

[origin: WO03063801A2] A method comprising exposing tumor cells to ethanol has been found to preserve the tumor cells during storage. As compared to control cells, tumor cells are preserved for a longer time, and retain display of antigen. In a specific embodiment, modified or unmodified cells are exposed to a concentration of about 37.5% v/v ethanol for a period of about 10 minutes at about 4 °C. Methods of storing haptenized tumor cells and vaccine preparations are also provided. It has also been found that tumor cell vaccines which comprise mainly dead or non-Trypan Blue-excluding cells can have retained or even improved antigenicity as compared to live cells. Methods of preparing and using such vaccines are also described.

IPC 1-7

A61K 35/00; A61K 35/12; A61K 35/14; C12N 15/85

IPC 8 full level

A61K 39/00 (2006.01); C12N 5/09 (2010.01)

CPC (source: EP US)

A61K 39/0011 (2013.01 - EP US); A61K 39/461 (2023.05 - EP US); A61K 39/46449 (2023.05 - EP US); A61K 2239/57 (2023.05 - US); A61P 35/00 (2018.01 - EP); C12N 5/0693 (2013.01 - EP US); A61K 2039/5152 (2013.01 - EP US); A61K 2039/55594 (2013.01 - EP US); A61K 2039/6012 (2013.01 - EP US); A61K 2039/80 (2018.08 - EP US); A61K 2239/57 (2023.05 - EP)

Citation (search report)

  • [A] WO 0029554 A2 20000525 - UNIV JEFFERSON [US], et al
  • [E] WO 03063802 A2 20030807 - UNIV JEFFERSON [US], et al
  • [A] BERD D: "Autologous, hapten-modified vaccine as a treatment for human cancers.", VACCINE. 21 MAR 2001, vol. 19, no. 17-19, 21 March 2001 (2001-03-21), pages 2565 - 2570, XP004231081, ISSN: 0264-410X
  • [PX] SOJKA DOROTHY K ET AL: "Anti-metastatic activity of hapten-modified autologous tumor cell vaccine in an animal tumor model.", CANCER IMMUNOLOGY, IMMUNOTHERAPY : CII. JUN 2002, vol. 51, no. 4, June 2002 (2002-06-01), pages 200 - 208, XP002386099, ISSN: 0340-7004
  • [PX] BERD DAVID ET AL: "Effect of the dose and composition of an autologous hapten-modified melanoma vaccine on the development of delayed-type hypersensitivity responses.", CANCER IMMUNOLOGY, IMMUNOTHERAPY : CII. AUG 2002, vol. 51, no. 6, August 2002 (2002-08-01), pages 320 - 326, XP002386100, ISSN: 0340-7004
  • [PX] BERD DAVID: "Contribution of dead cells to the immunogenicity of an autologous, hapten-modified melanoma vaccine.", VACCINE. 30 JAN 2003, vol. 21, no. 7-8, 30 January 2003 (2003-01-30), pages 795 - 797, XP004401627, ISSN: 0264-410X

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

DOCDB simple family (publication)

WO 03063801 A2 20030807; WO 03063801 A3 20050421; CA 2474954 A1 20030807; EP 1539197 A2 20050615; EP 1539197 A4 20060802; US 2003170756 A1 20030911

DOCDB simple family (application)

US 0303321 W 20030203; CA 2474954 A 20030203; EP 03710844 A 20030203; US 35711003 A 20030203