EP 1539672 A4 20060222 - PREPARATION METHOD OF VALIENAMINE FROM ACARBOSE AND/OR ACARBOSE DERIVATIVES USING TRIFLUOROACETIC ACID
Title (en)
PREPARATION METHOD OF VALIENAMINE FROM ACARBOSE AND/OR ACARBOSE DERIVATIVES USING TRIFLUOROACETIC ACID
Title (de)
VERFAHREN ZUR HERSTELLUNG VON VALIENAMIN AUS ACARBOSE UND/ODER ACARBOSEDERIVATEN UNTER VERWENDUNG VON TRIFLUORESSIGSûURE
Title (fr)
PROCEDE DE PREPARATION DE VALIENAMINE A PARTIR D'ACARBOSE ET/OU DE DERIVES D'ACARBOSE A L'AIDE D'ACIDE TRIFLUOROACETIQUE
Publication
Application
Priority
- KR 0202198 W 20021123
- KR 20020035683 A 20020625
- KR 20020051511 A 20020829
Abstract (en)
[origin: WO2004000782A1] The present invention relates to a preparation method of valienamine from acarbose and/or acarbose derivatives using organic acid TFA(trifluoroacetic acid). By using the method of the present invention, valienamine, the core precursor of voglibose which is a strong retardant of alpha-glucosidase and which is used for the cure of diabetes, can be produced in large quantities by using selective hydrolysis from acarbose and/or acarbose derivatives using TFA.
IPC 1-7
IPC 8 full level
C07C 213/00 (2006.01); A61K 31/704 (2006.01); C07B 61/00 (2006.01); C07C 29/14 (2006.01); C07C 209/62 (2006.01); C07C 215/44 (2006.01); C07F 9/54 (2006.01)
CPC (source: EP US)
C07C 213/00 (2013.01 - EP US); C07F 9/54 (2013.01 - EP US); C07C 2601/10 (2017.04 - EP US)
C-Set (source: EP US)
Citation (search report)
- [A] KAPFERER, P. ET AL: "Carbasaccharides via ring-closing alkene metathesis. A synthesis of (+)-valienamine from D- glucose", HELVETICA CHIMICA ACTA , 82(5), 645-656 CODEN: HCACAV; ISSN: 0018-019X, 1999, XP002359206
- See references of WO 2004000782A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 2004000782 A1 20031231; AU 2002368036 A1 20040106; CN 1282638 C 20061101; CN 1630630 A 20050622; EP 1539672 A1 20050615; EP 1539672 A4 20060222; JP 2005530839 A 20051013; US 2005272674 A1 20051208; US 7365192 B2 20080429
DOCDB simple family (application)
KR 0202198 W 20021123; AU 2002368036 A 20021123; CN 02829209 A 20021123; EP 02790977 A 20021123; JP 2004515194 A 20021123; US 51951905 A 20050801