EP 1539809 A2 20050615 - HCV FUSION PROTEINS WITH MODIFIED NS3 DOMAINS
Title (en)
HCV FUSION PROTEINS WITH MODIFIED NS3 DOMAINS
Title (de)
HCV-FUSIONSPROTEINE MIT MODIFIZIERTEN NS3-DOMÄNEN
Title (fr)
PROTEINES HYBRIDES DE VHC A DOMAINES NS3 MODIFIES
Publication
Application
Priority
- US 0320996 W 20030702
- US 39369402 P 20020702
- US 39451002 P 20020708
Abstract (en)
[origin: WO2004005473A2] The invention provides HCV fusion proteins that include a mutated NS3 protease domain, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating a cellular immune response to HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4<+> and CD8<+> T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 31/20 (2006.01); C07K 14/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/50 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP)
A61P 31/14 (2017.12); A61P 31/20 (2017.12); C07K 14/005 (2013.01); C12N 9/506 (2013.01); C07K 2319/00 (2013.01); C12N 2770/24222 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004005473 A2 20040115; WO 2004005473 A3 20040401; AU 2003248818 A1 20040123; CA 2491508 A1 20040115; CN 1678630 A 20051005; EP 1539809 A2 20050615; EP 1539809 A4 20060308; JP 2005532064 A 20051027; JP 2006265267 A 20061005; PL 374349 A1 20051017; RU 2005102484 A 20060120
DOCDB simple family (application)
US 0320996 W 20030702; AU 2003248818 A 20030702; CA 2491508 A 20030702; CN 03820719 A 20030702; EP 03763172 A 20030702; JP 2004519849 A 20030702; JP 2006174595 A 20060623; PL 37434903 A 20030702; RU 2005102484 A 20030702