Global Patent Index - EP 1539931 A4

EP 1539931 A4 20060823 - DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR

Title (en)

DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR

Title (de)

DIFFERENZIERUNGSMODULIERENDE AGENTIEN UND VERWENDUNGEN DAFÜR

Title (fr)

AGENTS DE MODULATION DE LA DIFFERENCIATION ET UTILISATIONS ASSOCIEES

Publication

EP 1539931 A4 20060823 (EN)

Application

EP 03735152 A 20030627

Priority

  • AU 0300826 W 20030627
  • US 39213002 P 20020627

Abstract (en)

[origin: WO2004003179A1] This invention discloses methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signaling pathway, especially the FGF-1 or FGF-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.

IPC 1-7

C12N 5/02; A61K 38/00

IPC 8 full level

G01N 33/50 (2006.01); A61K 38/18 (2006.01); A61K 45/00 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 16/18 (2006.01); C12N 5/02 (2006.01); C12N 5/077 (2010.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/74 (2006.01)

CPC (source: EP)

A61K 38/1825 (2013.01); A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 7/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 16/18 (2013.01); C12N 5/0653 (2013.01); G01N 33/74 (2013.01); C12N 2501/113 (2013.01); C12N 2501/115 (2013.01); C12N 2502/13 (2013.01); C12N 2502/28 (2013.01); G01N 2500/02 (2013.01)

Citation (search report)

  • [A] EP 1202065 A1 20020502 - AVENTIS PHARMA SA [FR], et al
  • [Y] EP 0420081 A1 19910403 - TAKEDA CHEMICAL INDUSTRIES LTD [JP]
  • [X] WO 0071129 A1 20001130 - BRISTOL MYERS SQUIBB CO [US]
  • [X] WO 0149849 A1 20010712 - ZYMOGENETICS INC [US]
  • [X] WO 0170977 A2 20010927 - AMGEN INC [US], et al
  • [E] WO 03099796 A1 20031204 - CYTOPIA PTY LTD [AU], et al
  • [E] WO 2004001059 A2 20031231 - BRISTOL MYERS SQUIBB CO [US], et al
  • [Y] COSIC IRENA ET AL: "In vitro inhibition of the actions of basic FGF by a novel 16 amino acid peptide", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 130, no. 1, 1994, pages 1 - 9, XP009062598, ISSN: 0300-8177
  • [Y] KRIEGER-BRAUER HEIDEMARIE I ET AL: "Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H-2O-2 generation in 3T3 L1-cells", BIOCHEMICAL JOURNAL, vol. 307, no. 2, 1995, pages 549 - 556, XP002370033, ISSN: 0264-6021
  • [Y] KAWAGUCHI NOBUKO ET AL: "De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, no. 3, 3 February 1998 (1998-02-03), pages 1062 - 1066, XP002370034, ISSN: 0027-8424
  • See references of WO 2004003179A1

Citation (examination)

  • ORNITZ D M ET AL: "RECEPTOR SPECIFICITY OF THE FIBROBLAST GROWTH FACTOR FAMILY", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 271, no. 25, 21 June 1996 (1996-06-21), pages 15292 - 15297, XP002919936, ISSN: 0021-9258, DOI: 10.1074/jbc.271.25.15292
  • RUSSELL T R ET AL: "CONVERSION OF 3T3 FIBROBLASTS INTO ADIPOSE CELLS: TRIGGERING OF DIFFERENTIATION BY PROSTAGLANDIN F2ALPHA AND I-METHYL-3-ISOBUTYL XANTHINE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 12, no. 73, 1 December 1976 (1976-12-01), pages 4516 - 4520, XP001079689, ISSN: 0027-8424, DOI: 10.1073/pnas.73.12.4516
  • SASAKI K ET AL: "EFFECTS OF FRIBROBLAST GROWTH FACTROS AND RELATED PEPTIDES ON FOOD INTAKE BY RATS", PHYSIOLOGY AND BEHAVIOR, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 56, no. 2, 1 January 1994 (1994-01-01), pages 211 - 218, XP000943197, ISSN: 0031-9384, DOI: 10.1016/0031-9384(94)90186-4
  • SCHMIDT ET AL: "Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 26, 1 September 1990 (1990-09-01), pages 15489 - 15495, XP055072329, ISSN: 0021-9258
  • SERRERO G ET AL: "Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 212, no. 3, 26 July 1995 (1995-07-26), pages 1125 - 1132, XP008081146, ISSN: 0006-291X, DOI: 10.1006/bbrc.1995.2085
  • HAUNER H ET AL: "Effects of epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) on human adipocyte development and function.", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION FEB 1995, vol. 25, no. 2, February 1995 (1995-02-01), pages 90 - 96, XP000198734, ISSN: 0014-2972, DOI: 10.1111/j.1365-2362.1995.tb01532.x
  • R. T. BOTTCHER ET AL: "Fibroblast Growth Factor Signaling during Early Vertebrate Development", ENDOCRINE REVIEWS, vol. 26, no. 1, 1 February 2005 (2005-02-01), pages 63 - 77, XP055072332, ISSN: 0163-769X, DOI: 10.1210/er.2003-0040
  • SASAKI K ET AL: "Actions of acidic fibroblast growth factor fragments on food intake in rats", OBESITY RESEARCH, BATON ROUGE, LA, US, vol. 3, no. Suppl 5, 1 December 1995 (1995-12-01), pages 697S - 706S, ISSN: 1071-7323
  • MILLER ET AL: "Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 6, 1 March 2000 (2000-03-01), pages 2260 - 2268, XP055072326, ISSN: 0270-7306

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004003179 A1 20040108; AU 2003236557 A1 20040119; AU 2003236557 B2 20091001; AU 2009251219 A1 20100128; AU 2009251219 B2 20130110; CA 2490261 A1 20040108; CN 1678734 A 20051005; CN 1678734 B 20121212; EP 1539931 A1 20050615; EP 1539931 A4 20060823; EP 2267117 A2 20101229; EP 2267117 A3 20110713; JP 2005535629 A 20051124; JP 2010215636 A 20100930; NZ 537208 A 20090228

DOCDB simple family (application)

AU 0300826 W 20030627; AU 2003236557 A 20030627; AU 2009251219 A 20091224; CA 2490261 A 20030627; CN 03820407 A 20030627; EP 03735152 A 20030627; EP 10184571 A 20030627; JP 2004516341 A 20030627; JP 2010106139 A 20100506; NZ 53720803 A 20030627