EP 1542733 A2 20050622 - IMPROVED METHOD TO IDENTIFY TARGETING MOLECULES
Title (en)
IMPROVED METHOD TO IDENTIFY TARGETING MOLECULES
Title (de)
VERBESSERTES VERFAHREN ZUR IDENTIFIZIERUNG VON TARGETING-MOLEK LEN
Title (fr)
PROCEDE AMELIORE D'IDENTIFICATION DE MOLECULES DE CIBLAGE
Publication
Application
Priority
- US 0324994 W 20030808
- US 40237202 P 20020808
- US 74092703 P 20030514
Abstract (en)
[origin: WO2004015392A2] Methods for validating the in vivo targeting specificity of compounds according to pharmacokinetic criteria are described. An improved method to generate a library of peptides with reduced complexity and enhanced candidate compound membership comprises expressing oligonucleotides encoding cyclic peptides with randomized coding sequences representing the non-bridging amino acids. Also described is determination of structure activity relationships using kinetic technique using in vivo panning. Design of targeting compounds with appropriate space/charge/hydrophobicity conformations can be based on the results of these kinetic structure activity relationship (kSAR) determinations. In addition, compositions resulting from this methodology are useful in treating neuroinflammatory and lung disorders, and disorders involving disseminated blood cell coagulopathy interactions with vascular endothelium.
IPC 1-7
IPC 8 full level
A61K 49/00 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 49/0002 (2013.01); A61K 49/0004 (2013.01); C07K 5/1013 (2013.01); C07K 7/06 (2013.01); G01N 33/5088 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 2004015392A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004015392 A2 20040219; WO 2004015392 A3 20040729; AU 2003264030 A1 20040225; AU 2003264030 A8 20040225; CA 2494551 A1 20040219; EP 1542733 A2 20050622
DOCDB simple family (application)
US 0324994 W 20030808; AU 2003264030 A 20030808; CA 2494551 A 20030808; EP 03785119 A 20030808