EP 1542977 A1 20050622 - 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12.
Title (en)
2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12.
Title (de)
2,5-DIOXOIMIDAZOLIDIN-4-YLACETAMIDE UND ANALOGA ALS INHIBITOREN VON METALLOPROTEINASE MMP12
Title (fr)
2,5-DIOXOIMIDAZOLIDINE-4-YL ACETAMIDES ET ANALOGUES SERVANT D'INHIBITEURS DE LA METALLOPROTEINASE MMP12.
Publication
Application
Priority
- SE 0301328 W 20030826
- SE 0202539 A 20020827
Abstract (en)
[origin: WO2004020415A1] The invention provides compounds of formula (I) in which L, X, Y, Z<1>, Z<2>, R<1>, R<2>, R<3> and G<2> have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds of the invention are inhibitors of metalloproteinase MMP12 and are among other things useful for the treatment of obstructive airways diseases, such as asthma and chronic obstructive pulmonary disease (COPD).
IPC 1-7
C07D 233/78; A61K 31/4166; A61P 11/06; A61P 17/02; A61P 17/06; A61P 19/00; A61P 25/28; A61P 29/00; A61P 35/00; A61P 37/00; A61P 41/00
IPC 8 full level
C07D 233/78 (2006.01); A61K 31/4166 (2006.01); A61P 11/06 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 41/00 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP KR US)
A61K 31/4164 (2013.01 - KR); A61P 1/02 (2018.01 - EP); A61P 1/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 17/02 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/00 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 19/06 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 41/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 233/78 (2013.01 - EP KR US); C07D 401/12 (2013.01 - EP KR US); C07D 403/12 (2013.01 - EP KR US); C07D 405/12 (2013.01 - EP KR US); C07D 409/12 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004020415 A1 20040311; AR 041066 A1 20050427; AT E348816 T1 20070115; AU 2003253557 A1 20040319; AU 2003253557 B2 20070329; BR 0313635 A 20050621; CA 2495853 A1 20040311; CN 100398521 C 20080702; CN 1688550 A 20051026; CY 1106027 T1 20110406; DE 60310582 D1 20070201; DE 60310582 T2 20071122; DK 1542977 T3 20070319; EP 1542977 A1 20050622; EP 1542977 B1 20061220; ES 2277143 T3 20070701; HK 1077061 A1 20060203; IL 166826 A 20090615; IS 2415 B 20081015; IS 7767 A 20050322; JP 2006503019 A 20060126; KR 20050059093 A 20050617; MX PA05002066 A 20050608; MY 137562 A 20090227; NO 20051540 L 20050323; NZ 538443 A 20060929; PL 375754 A1 20051212; PT 1542977 E 20070228; RU 2005103617 A 20060110; RU 2326117 C2 20080610; SE 0202539 D0 20020827; TW 200407313 A 20040516; TW I332500 B 20101101; UA 81635 C2 20080125; US 2005245586 A1 20051103; US 2006276524 A1 20061207; US 7354940 B2 20080408; US 7662845 B2 20100216; ZA 200501139 B 20061227
DOCDB simple family (application)
SE 0301328 W 20030826; AR P030103098 A 20030827; AT 03791528 T 20030826; AU 2003253557 A 20030826; BR 0313635 A 20030826; CA 2495853 A 20030826; CN 03823797 A 20030826; CY 071100216 T 20070216; DE 60310582 T 20030826; DK 03791528 T 20030826; EP 03791528 A 20030826; ES 03791528 T 20030826; HK 05109053 A 20051013; IL 16682605 A 20050210; IS 7767 A 20050322; JP 2004532506 A 20030826; KR 20057003210 A 20050225; MX PA05002066 A 20030826; MY PI20033211 A 20030825; NO 20051540 A 20050323; NZ 53844303 A 20030826; PL 37575403 A 20030826; PT 03791528 T 20030826; RU 2005103617 A 20030826; SE 0202539 A 20020827; TW 92122899 A 20030820; UA 2005001189 A 20030826; US 50020706 A 20060807; US 52564005 A 20050225; ZA 200501139 A 20050208