Global Patent Index - EP 1543324 A4

EP 1543324 A4 20051214 - METHODS AND COMPOSITIONS FOR GRAFTING FUNCTIONAL LOOPS INTO A PROTEIN

Title (en)

METHODS AND COMPOSITIONS FOR GRAFTING FUNCTIONAL LOOPS INTO A PROTEIN

Title (de)

VERFAHREN UND ZUSAMMENSETZUNGEN ZUR IMPLANTATION VON FUNKTIONALEN SCHLEIFEN IN EIN PROTEIN

Title (fr)

PROCEDES ET COMPOSITIONS POUR LA GREFFE DE BOUCLES FONCTIONNELLES DANS UNE PROTEINE

Publication

EP 1543324 A4 20051214 (EN)

Application

EP 03724564 A 20030512

Priority

  • US 0315017 W 20030512
  • US 17038702 A 20020612

Abstract (en)

[origin: US2003104591A1] The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.

IPC 1-7

G01N 33/53

IPC 8 full level

A61K 47/48 (2006.01); C12N 9/50 (2006.01); C12N 9/86 (2006.01); C12N 15/10 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP US)

A61K 47/6415 (2017.07 - EP US); A61K 47/67 (2017.07 - EP US); A61K 47/6891 (2017.07 - EP US); B82Y 5/00 (2013.01 - EP US); C07K 16/30 (2013.01 - EP US); C12N 9/00 (2013.01 - EP US); C12N 9/50 (2013.01 - US); C12N 9/64 (2013.01 - EP US); C12N 9/86 (2013.01 - EP US); C12N 15/1034 (2013.01 - EP US); C12N 15/1044 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); C07K 2318/10 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C07K 2319/50 (2013.01 - EP US); C07K 2319/55 (2013.01 - EP US); C07K 2319/70 (2013.01 - EP US)

Citation (search report)

  • [X] ROSS-MACDONALD PETRA ET AL: "A multipurpose transposon system for analyzing protein production, localization, and function in Saccharomyces cerevisiae", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, no. 1, 1997, pages 190 - 195, XP002148084, ISSN: 0027-8424
  • [X] HAYES FINBARR ET AL: "Insertion mutagenesis as a tool in the modification of protein function. Extended substrate specificity conferred by pentapeptide insertions in the OMEGA-loop of TEM-1 beta-lactamase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 46, 14 November 1997 (1997-11-14), pages 28833 - 28836, XP002349313, ISSN: 0021-9258
  • [X] HAYES F ET AL: "Pentapeptide scanning mutagenesis: encouraging old proteins to execute unusual tricks", TRENDS IN MICROBIOLOGY, ELSEVIER SCIENCE LTD., KIDLINGTON, GB, vol. 8, no. 12, December 2000 (2000-12-01), pages 571 - 577, XP002241076, ISSN: 0966-842X
  • [X] GALARNEAU A ET AL: "Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 20, no. 6, June 2002 (2002-06-01), pages 619 - 622, XP002279639, ISSN: 1087-0156
  • [A] LU Z ET AL: "EXPRESSION OF THIOREDOXIN RANDOM PEPTIDE LIBRARIES ON THE ESCHERICHIA COLI CELL SURFACE AS FUNCTIONAL FUSIONS TO FLAGELLIN: A SYSTEM DESIGNED FOR EXPLORING PROTEIN-PROTEIN INTERACTIONS", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 13, April 1995 (1995-04-01), pages 366 - 372, XP002033346, ISSN: 0733-222X
  • [PX] CHIANG S L ET AL: "Construction of a mariner-based transposon for epitope-tagging and genomic targeting", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 296, no. 1-2, 21 August 2002 (2002-08-21), pages 179 - 185, XP004386954, ISSN: 0378-1119
  • See references of WO 03105753A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

US 2003104591 A1 20030605; AU 2003235506 A1 20031231; AU 2003235506 A8 20031231; CA 2488821 A1 20031224; CA 2488821 C 20130416; DE 60317687 D1 20080103; DE 60317687 T2 20081030; DK 1543324 T3 20080407; EP 1543324 A2 20050622; EP 1543324 A4 20051214; EP 1543324 B1 20071121; US 2004203107 A1 20041014; WO 03105753 A2 20031224; WO 03105753 A3 20050421

DOCDB simple family (application)

US 17038702 A 20020612; AU 2003235506 A 20030512; CA 2488821 A 20030512; DE 60317687 T 20030512; DK 03724564 T 20030512; EP 03724564 A 20030512; US 0315017 W 20030512; US 83996204 A 20040507