EP 1545209 A4 20090729 - FACTORS THAT BIND INTESTINAL TOXINS
Title (en)
FACTORS THAT BIND INTESTINAL TOXINS
Title (de)
DARMTOXINBINDENDE FAKTOREN
Title (fr)
FACTEURS DE LIAISON A DES TOXINES BACTERIENNES
Publication
Application
Priority
- US 0328282 W 20030909
- US 40974202 P 20020910
Abstract (en)
[origin: WO2004024070A2] Methods for neutralizing bacterial toxins such as Shiga toxins and cholera toxins are disclosed. In a particular embodiment, a method is provided for treating a subject suffering from an infection caused by an Stx-producing organism by administering a therapeutically effective amount of a hop bract tannin obtained from Humulus lupulus. Also provided are methods for isolating polyphenolic compounds that bind Stx molecules, and methods for detecting the presence of Stx molecules in a biological sample. In a disclosed embodiment, a subject infected with a Shiga toxin-producing E. coli strain is treated by enterically administering a high molecular weight fraction of hop bract extract to the subject.
IPC 1-7
IPC 8 full level
A01N 43/16 (2006.01); A61K 45/06 (2006.01)
IPC 8 main group level
A61K (2006.01)
CPC (source: EP)
A61K 45/06 (2013.01); A61P 1/00 (2017.12); A61P 31/04 (2017.12); A61P 39/02 (2017.12); Y02A 50/30 (2017.12)
Citation (search report)
- [XA] JP 2001321166 A 20011120 - ASAHI BREWERIES LTD
- [XA] GB 2330076 A 19990414 - STEINER INC S S [US]
- [T] MORINAGA NAOKO ET AL: "Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 24, June 2005 (2005-06-01), pages 23303 - 23309, XP002531884, ISSN: 0021-9258
- See references of WO 2004024070A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004024070 A2 20040325; WO 2004024070 A3 20040805; AU 2003267079 A1 20040430; AU 2003267079 B2 20080814; CA 2498225 A1 20040325; EP 1545209 A2 20050629; EP 1545209 A4 20090729; JP 2006508924 A 20060316
DOCDB simple family (application)
US 0328282 W 20030909; AU 2003267079 A 20030909; CA 2498225 A 20030909; EP 03749554 A 20030909; JP 2004536403 A 20030909