EP 1545489 A4 20060823 - TREATMENT OF DEPRESSION SECONDARY TO PAIN (DSP)
Title (en)
TREATMENT OF DEPRESSION SECONDARY TO PAIN (DSP)
Title (de)
BEHANDLUNG VON DEPRESSION ALS SEKUNDûRE FOLGEN VON SCHMERZEN (DSP)
Title (fr)
TRAITEMENT DE LA DEPRESSION CONSECUTIVE A LA DOULEUR
Publication
Application
Priority
- US 0323088 W 20030724
- US 39867602 P 20020724
- US 44303503 P 20030128
Abstract (en)
[origin: WO2004009069A1] Methods for the prevention or treatment of atypical depression secondary to pain (DSP) have been developed. The method generally involves administering an effective amount of a monoamine re uptake inhibitor to treat or prevent symptoms of DSP. In a preferred embodiment, a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor (SRNI) compound of a specific type, or a pharmaceutically acceptable sait thereof is administered. The most preferred SNRI compounds are non-tricyclic SNRIs, wherein serotonin reuptake inhibition is greater than norepinephrine reuptake inhibition; and NSRIs, wherein norepinephrine reuptake inhibition is greater than serotonin reuptake inhibition. The most preferred compound is milnacipran or a bioequivalent or pharmaceutically acceptable sait thereof. Other preferred compounds are duloxetine and venlafaxine or a bioequivalent or pharmaceutically acceptable salt thereof. In yet another embodiment, a therapeutically effective amount of a non-tricyclic triple reuptake inhibitor ("TRI") compound of a specific type, or a pharmaceutically acceptable sait thereof, is administered. The TRI compounds are characterized by their ability to block the reuptake (and, hence, increase central concentrations of) the three primary brain monoamines: serotonin, noradrenaline, and dopamine.
IPC 1-7
IPC 8 full level
A61K 31/131 (2006.01); A61K 31/135 (2006.01); A61K 31/165 (2006.01)
CPC (source: EP)
A61K 31/131 (2013.01); A61K 31/135 (2013.01); A61K 31/165 (2013.01); A61P 25/02 (2017.12); A61P 25/24 (2017.12)
Citation (search report)
- [XP] WO 03039598 A1 20030515 - CYPRESS BIOSCIENCE INC [US]
- [X] WO 9400114 A1 19940106 - SEPRACOR INC [US]
- [X] "Martindale", 1999, PHARMACEUTICAL PRESS, LONDON, XP002387013, 32
- [X] SPENCER CAROLINE M ET AL: "Milnacipran: A review of its use in depression", DRUGS, ADIS INTERNATIONAL LTD, AT, vol. 56, no. 3, September 1998 (1998-09-01), pages 405 - 427, XP008021105, ISSN: 0012-6667
- [X] RUOFF G E: "Depression in the patient with chronic pain.", THE JOURNAL OF FAMILY PRACTICE. DEC 1996, vol. 43, no. 6 Suppl, December 1996 (1996-12-01), pages S25 - S33 ; dis, XP008065739, ISSN: 0094-3509
- [X] BARKIN R L ET AL: "The management challenges of chronic pain: the role of antidepressants.", AMERICAN JOURNAL OF THERAPEUTICS. JAN 2000, vol. 7, no. 1, January 2000 (2000-01-01), pages 31 - 47, XP008065677, ISSN: 1075-2765
- See references of WO 2004009069A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004009069 A1 20040129; AU 2003268020 A1 20040209; CA 2493490 A1 20040129; CN 1671368 A 20050921; EP 1545489 A1 20050629; EP 1545489 A4 20060823; MX PA05000566 A 20050829
DOCDB simple family (application)
US 0323088 W 20030724; AU 2003268020 A 20030724; CA 2493490 A 20030724; CN 03817458 A 20030724; EP 03748971 A 20030724; MX PA05000566 A 20030724