EP 1546132 A1 20050629 - PYRAZOLE DERIVATIVES AS REVERSE TRANSCRIPTASE INHIBITORS
Title (en)
PYRAZOLE DERIVATIVES AS REVERSE TRANSCRIPTASE INHIBITORS
Title (de)
PYRAZOLE DERIVATE ALS REVERSE TRANSCRIPTASE INHIBITOREN
Title (fr)
DERIVES DE PYRAZOLE UTILISES EN TANT QU'INHIBITEURS DE LA TRANSCRIPTASE INVERSE
Publication
Application
Priority
- GB 0222374 A 20020926
- GB 0223356 A 20021008
- IB 0304158 W 20030915
Abstract (en)
[origin: WO2004029042A1] This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R' to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
IPC 1-7
C07D 401/12; A61K 31/415; A61K 31/4155; C07D 231/28; C07D 403/12; C07D 417/12; A61P 31/18
IPC 8 full level
A61P 31/18 (2006.01); C07D 231/28 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61P 31/14 (2017.12); A61P 31/18 (2017.12); A61P 43/00 (2017.12); C07D 231/28 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 417/12 (2013.01)
Citation (search report)
See references of WO 2004029042A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004029042 A1 20040408; AU 2003260908 A1 20040419; BR 0314709 A 20050726; CA 2497333 A1 20040408; EP 1546132 A1 20050629; JP 2006504803 A 20060209; MX PA05003195 A 20050608
DOCDB simple family (application)
IB 0304158 W 20030915; AU 2003260908 A 20030915; BR 0314709 A 20030915; CA 2497333 A 20030915; EP 03798326 A 20030915; JP 2005501943 A 20030915; MX PA05003195 A 20030915