EP 1546186 A1 20050629 - METHOD FOR SYNTHESIZING PEPTIDES
Title (en)
METHOD FOR SYNTHESIZING PEPTIDES
Title (de)
VERFAHREN ZUR SYNTHESE VON PEPTIDEN
Title (fr)
PROCEDE DE SYNTHESE DE PEPTIDES
Publication
Application
Priority
KR 0201604 W 20020826
Abstract (en)
[origin: WO2004018501A1] The present invention relates to a novel method for synthesizing peptides in solution, the method comprising: a) treating a peptide or amino acid derivative, which has an alpha-amine function blocked with a urethane group of the formula R<1>-SO2-CH2CH2-O-CO-, wherein R<1> is aryl, with an excess of an aliphatic secondary amine in an organic solvent to provide the release of the free alpha-amine function of said amino acid or peptide derivative and the formation of a tertiary amine adduct between said secondary amine and the liberated vinyl compound of the formula R<1>-SO2-CH2=CH2; b) removing the solvent and the excess of said secondary amine; c) contacting thus formed mixture of the Nalpha-deprotected amino acid or peptide derivative and said tertiary amine adduct with subsequent peptide or amino acid derivative Nalpha-protected with the above indicated or another urethane group under conditions providing the formation of a peptide bond between the free alpha-amine function of the Nalpha-deprotected amino acid or peptide derivative and an alpha-carboxylic function of the subsequent Nalpha-protected peptide or amino acid derivative; d) separating the newly formed peptide from the reaction mixture; e) repeating procedures as set forth above until the desired polypeptide is obtained.
IPC 1-7
IPC 8 full level
C07K 1/02 (2006.01); C07K 1/04 (2006.01); C07K 1/06 (2006.01)
CPC (source: EP)
C07K 1/02 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 2004018501 A1 20040304; AU 2002329070 A1 20040311; CA 2496739 A1 20040304; CN 1649892 A 20050803; EP 1546186 A1 20050629; EP 1546186 A4 20060208; JP 2006511459 A 20060406
DOCDB simple family (application)
KR 0201604 W 20020826; AU 2002329070 A 20020826; CA 2496739 A 20020826; CN 02829521 A 20020826; EP 02765630 A 20020826; JP 2004530625 A 20020826