Global Patent Index - EP 1551973 A4

EP 1551973 A4 20060607 - NEW GDF-9 AND GDF-9B (BMP-15) SEQUENCES FOR ALTERING MAMMALIAN OVARIAN FUNCTION AND OVULATION RATE

Title (en)

NEW GDF-9 AND GDF-9B (BMP-15) SEQUENCES FOR ALTERING MAMMALIAN OVARIAN FUNCTION AND OVULATION RATE

Title (de)

NEUE GDF-9 UND GDF-9B (BMP-15) SEQUENZEN FÜR DIE VERÄNDERUNG DER EILEITERFUNKTION VON SÄUGETIEREN UND DER OVULATIONSRATE

Title (fr)

NOUVELLES SEQUENCES GDF-9 ET GDF-9B (BMP-15) DESTINEES A MODIFIER LA FONCTION OVARIENNE ET LA VITESSE D'OVULATION CHEZ DES MAMMIFERES

Publication

EP 1551973 A4 20060607 (EN)

Application

EP 03723538 A 20030530

Priority

  • NZ 0300109 W 20030530
  • NZ 51933002 A 20020530

Abstract (en)

[origin: WO03102199A1] The present invention provides compositions and methods for modulating the ovulation rate and therefore fertility in female mammals including humans. The invention also relates to novel mutations in the GDF-9 and GDF-9B genes which are associated with changes in fertility.

IPC 1-7

C12N 15/12; A61K 38/16; A61K 39/395; A61P 15/00

IPC 8 full level

A01K 67/027 (2006.01); A61P 15/00 (2006.01); C07K 14/475 (2006.01); C07K 16/42 (2006.01); C12N 15/12 (2006.01)

CPC (source: EP)

A01K 67/027 (2013.01); A61P 15/00 (2017.12); A61P 15/18 (2017.12); C07K 14/475 (2013.01); C07K 16/4241 (2013.01); A01K 2217/075 (2013.01); A61K 2039/505 (2013.01)

Citation (search report)

  • [X] BODENSTEINER K J ET AL: "Molecular cloning of the ovine growth/differentiation factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 60, no. 2, February 1999 (1999-02-01), pages 381 - 386, XP002192638, ISSN: 0006-3363
  • [DA] HANRAHAN J P: "Evidence for single gene effects on ovulation rate in the Cambridge and Beclare breeds", [INRA COLLOQUIA; MAJOR GENES FOR REPRODUCTION IN SHEEP] INRA (INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE) {A}, 147 RUE DE L'UNIVERSITE, 75007 PARIS, FRANCE SERIES : COLLOQUES DE L'INRA (ISSN 0293-1915), 1991, & 2ND INTERNATIONAL WORKSHOP; TOULOUSE, FRANCE; JULY 16-18, 1990, pages 93 - 102, XP008056997, ISSN: 2-7380-0337-0
  • [DA] GALLOWAY SUSAN M ET AL: "Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 25, no. 3, July 2000 (2000-07-01), pages 279 - 283, XP002188991, ISSN: 1061-4036
  • [T] HANRAHAN JAMES P ET AL: "Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).", BIOLOGY OF REPRODUCTION, vol. 70, no. 4, April 2004 (2004-04-01), pages 900 - 909, XP008056979, ISSN: 0006-3363 & DATABASE EMBL [online] 4 August 1998 (1998-08-04), "Ovis aries growth differentiation factor-9 gene, complete cds.", XP002358265, retrieved from EBI accession no. EM_PRO:AF078545 Database accession no. AF078545
  • See references of WO 03102199A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 03102199 A1 20031211; AU 2003235525 A1 20031219; AU 2003235525 B2 20080911; BR 0311465 A 20050405; CA 2490051 A1 20031211; EP 1551973 A1 20050713; EP 1551973 A4 20060607; JP 2006510345 A 20060330; NZ 519330 A 20041224

DOCDB simple family (application)

NZ 0300109 W 20030530; AU 2003235525 A 20030530; BR 0311465 A 20030530; CA 2490051 A 20030530; EP 03723538 A 20030530; JP 2004510436 A 20030530; NZ 51933002 A 20020530