EP 1554255 A1 20050720 - METHOD FOR THE PRODUCTION OF 2-AMINO-4-CHLORO-6-ALKOXYPYRIMIDINES
Title (en)
METHOD FOR THE PRODUCTION OF 2-AMINO-4-CHLORO-6-ALKOXYPYRIMIDINES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 2-AMINO-4-CHLOR-6-ALKOXYPYRIMIDINEN
Title (fr)
PROCEDE DE PRODUCTION DE 2-AMINO-4-CHLOR-6-ALCOXYPYRIMIDINES
Publication
Application
Priority
- DE 10249946 A 20021026
- EP 0311844 W 20031024
Abstract (en)
[origin: WO2004037795A1] The invention relates to a method for producing 2-amino-4-chloro-6-alkoxypyrimidines by reacting 2-amino-4,6-dichloropyrimidine with an alkali alcoholate or a mixture of alkali hydroxides and an alcohol in a polar aprotic solvent (mixture), whereupon the solvent is distilled off to > 30 percent and the product is precipitated by adding water during or following the distillation process. The inventive method, in which especially acetone is used as a polar aprotic solvent and which can be carried out at temperatures between 5 and 60 DEG C, allows 2-amino-4-chloro-6-alkoxypyrimidines and above all 2-amino-4-chloro-6-methoxypyrimidine to be produced in a particularly economical and environmentally friendly manner while obtaining high yields and a very distinctive purity.
IPC 1-7
IPC 8 full level
C07D 239/46 (2006.01)
CPC (source: EP US)
C07D 239/47 (2013.01 - EP US)
Citation (search report)
See references of WO 2004037795A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004037795 A1 20040506; DE 10249946 A1 20040519; DE 10249946 B4 20050623; EP 1554255 A1 20050720; JP 2006512305 A 20060413; US 2006035913 A1 20060216
DOCDB simple family (application)
EP 0311844 W 20031024; DE 10249946 A 20021026; EP 03775230 A 20031024; JP 2004545989 A 20031024; US 52895905 A 20050322