EP 1558566 A1 20050803 - NOVEL PHENYLNAPHTHALENE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
Title (en)
NOVEL PHENYLNAPHTHALENE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
Title (de)
NEUE PHENYLNAPHTALINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND SIE ENTHALTENDE ARZNEIMITTELGEMISCHE
Title (fr)
NOUVEAUX DERIVES DU PHENYLNAPHTALENE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Publication
Application
Priority
- FR 0303278 W 20031104
- FR 0213917 A 20021107
Abstract (en)
[origin: FR2846963A1] 1-(Amido-, ureido- or carbamoyl-alkyl)-3-(substituted methyl-phenyl)-naphthalene derivatives (I) are new. Phenyl-naphthalene derivatives of formula (I) and their enantiomers, diastereomers and acid or base addition salts are new. A = -NR2-CO-R1, -NR2-CO-NR1R'1 or -CO-NR1R'1; R1, R'1 = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl, (3-8C) cycloalkyl-(1-6C) alkyl, aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; R2 = H or alkyl; or R1 + R2 = 3-6C linear or branched alkylene; R3 = 1-6C alkoxy; R4 = halo, OH, 1-6C alkoxy, NH2 or mono- or di-(1-6C alkyl)-amino; aryl moieties = phenyl, naphthyl or biphenylyl (all optionally substituted by 1-3 of 1-6C alkyl, 1-6C alkoxy, OH, COOH, CHO, NO2, CN, 1-6C polyhaloalkyl, alkoxycarbonyl or halo); p = 1-3; heteroaryl moieties = mono- or bicyclic aromatic group containing 1-3 of O, S and N as heteroatom(s) (optionally substituted as for aryl). Independent claims are included for: (a) the preparation of (I); and (b) new alkoxycarbonylphenyl-naphthalene derivative intermediates of formula (V) and their enantiomers, diastereomers and acid or base addition salts. R'5 = (1-6C) alkoxycarbonyl.
IPC 1-7
C07C 233/18; C07C 233/36; C07C 233/60; C07D 207/27; A61K 31/16; A61K 31/40; A61P 25/00; A61P 3/00
IPC 8 full level
A61P 1/00 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 15/18 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07C 233/18 (2006.01); C07C 233/36 (2006.01); C07C 233/60 (2006.01); C07D 207/27 (2006.01); C07D 207/26 (2006.01)
CPC (source: EP KR US)
A61K 31/16 (2013.01 - KR); A61P 1/00 (2017.12 - EP); A61P 1/14 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/10 (2017.12 - EP); A61P 15/18 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 233/18 (2013.01 - EP KR US); C07C 233/36 (2013.01 - EP KR US); C07C 233/60 (2013.01 - EP KR US); C07D 207/27 (2013.01 - EP KR US); C07C 2601/04 (2017.04 - EP US)
Citation (search report)
See references of WO 2004043907A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated extension state (EPC)
AL LT LV MK
DOCDB simple family (publication)
FR 2846963 A1 20040514; FR 2846963 B1 20060714; AR 042004 A1 20050608; AU 2003292324 A1 20040603; BR 0316095 A 20050927; CA 2503992 A1 20040527; CN 1324004 C 20070704; CN 1711235 A 20051221; EA 008250 B1 20070427; EA 200500720 A1 20051027; EP 1558566 A1 20050803; GE P20074181 B 20070810; HK 1081944 A1 20060526; JP 2006505604 A 20060216; KR 100682702 B1 20070215; KR 20050074553 A 20050718; MA 27409 A1 20050601; MX PA05004910 A 20050722; NO 20052757 D0 20050607; NO 20052757 L 20050607; NZ 539631 A 20061027; PL 376251 A1 20051227; UA 80580 C2 20071010; US 2006106111 A1 20060518; WO 2004043907 A1 20040527; ZA 200503232 B 20060628
DOCDB simple family (application)
FR 0213917 A 20021107; AR P030104102 A 20031107; AU 2003292324 A 20031104; BR 0316095 A 20031104; CA 2503992 A 20031104; CN 200380102715 A 20031104; EA 200500720 A 20031104; EP 03767890 A 20031104; FR 0303278 W 20031104; GE AP2003008835 A 20031104; HK 06102325 A 20060222; JP 2004550730 A 20031104; KR 20057008141 A 20050506; MA 28231 A 20050419; MX PA05004910 A 20031104; NO 20052757 A 20050607; NZ 53963103 A 20031104; PL 37625103 A 20031104; UA 2005005385 A 20031104; US 53411605 A 20050505; ZA 200503232 A 20050421