Global Patent Index - EP 1558626 A4

EP 1558626 A4 20071031 - TARGET DETECTION SYSTEM HAVING A CONFORMATIONALLY SENSITIVE PROBE COMPRISING A NUCLEIC ACID BASED SIGNAL TRANSDUCER

Title (en)

TARGET DETECTION SYSTEM HAVING A CONFORMATIONALLY SENSITIVE PROBE COMPRISING A NUCLEIC ACID BASED SIGNAL TRANSDUCER

Title (de)

SYSTEM ZUM NACHWEIS VON ZIELVERBINDUNGEN MIT KONFORMATIONSEMPFINDLICHER SONDE, ENTHALTEND EINEN SIGNALVERMITTLER AUFNUKLEINSÄUREBASIS

Title (fr)

SYSTEME DE DETECTION DE CIBLES AVEC SONDE SENSIBLE PAR SA CONFORMATION, COMPRENANT UN TRANSDUCTEUR DE SIGNAUX A BASE D'ACIDES NUCLEIQUES

Publication

EP 1558626 A4 20071031 (EN)

Application

EP 03751517 A 20031011

Priority

  • KR 0302101 W 20031011
  • US 41786402 P 20021011

Abstract (en)

[origin: WO2004033476A1] Disclosed is a system for detecting at least one target agent in a sample. The system generally includes at least one probe adapated to relate presence of the target agent to a detectable change in probe conformation. Preferred probes include a conformationally responsive signal transducer that reports association of the target agent and the probe by detectably shifting from one hybridization state to another. The invention has a wide spectrum of important applications including use in the rapid detection of target agents in biological, industrial, and environmental samples.

IPC 1-7

C12Q 1/68

IPC 8 full level

C12Q 1/68 (2006.01)

CPC (source: EP)

C12Q 1/6825 (2013.01)

Citation (search report)

  • [XA] US 5925517 A 19990720 - TYAGI SANJAY [US], et al
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  • [XY] WO 9709342 A1 19970313 - SCRIPTGEN PHARM INC [US]
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  • [Y] WO 0185997 A1 20011115 - QTL BIOSYSTEMS LLC [US]
  • [YA] US 5658732 A 19970819 - EBERSOLE RICHARD CALVIN [US], et al
  • [XA] MORRIS P D ET AL: "Biotin-streptavidin-labeled oligonucleotides as probes of helicase mechanisms.", METHODS (SAN DIEGO, CALIF.) FEB 2001, vol. 23, no. 2, February 2001 (2001-02-01), pages 149 - 159, XP002431731, ISSN: 1046-2023
  • [XA] RICCELLI P V ET AL: "Hybridization of single-stranded DNA targets to immobilized complementary DNA probes: comparison of hairpin versus linear capture probes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 29, no. 4, 15 February 2001 (2001-02-15), pages 996 - 1004, XP002282478, ISSN: 0305-1048
  • [XA] SOH J ET AL: "Hybrid selection of mRNA with biotinylated DNA.", GENETIC ANALYSIS, TECHNIQUES AND APPLICATIONS JUN 1990, vol. 7, no. 4, June 1990 (1990-06-01), pages 80 - 86, XP002431732, ISSN: 1050-3862
  • [XA] TYAGI S ET AL: "MOLECULAR BEACONS: PROBES THAT FLUORESCE UPON HYBRIDIZATION", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 14, March 1996 (1996-03-01), pages 303 - 308, XP002926498, ISSN: 0733-222X
  • [XY] FANG X ET AL: "Designing a novel molecular beacon for surface-immobilized DNA hybridization studies", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 121, no. 12, 31 March 1999 (1999-03-31), pages 2921 - 2922, XP002315845, ISSN: 0002-7863
  • [XY] BRIGATI D J ET AL: "Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes.", VIROLOGY 15 APR 1983, vol. 126, no. 1, 15 April 1983 (1983-04-15), pages 32 - 50, XP002431733, ISSN: 0042-6822
  • [XY] COOK A F ET AL: "SYNTHESIS AND HYBRIDIZATION OF A SERIES OF BIOTINYLATED OLIGONUCLEOTIDES", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 16, no. 9, 11 May 1988 (1988-05-11), pages 4077 - 4095, XP000453559, ISSN: 0305-1048
  • [Y] TELSER J ET AL: "Synthesis and characterization of DNA oligomers and duplexes containing covalently attached molecular labels: Comparison of biotin, fluorescein, and pyrene labels by thermodynamic and optical spectroscopic measurements", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 1989 UNITED STATES, vol. 111, no. 18, 1989, pages 6966 - 6976, XP002431734, ISSN: 0002-7863
  • See references of WO 2004033476A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004033476 A1 20040422; AU 2003269522 A1 20040504; EP 1558626 A1 20050803; EP 1558626 A4 20071031; JP 2006513701 A 20060427; JP 2010099090 A 20100506

DOCDB simple family (application)

KR 0302101 W 20031011; AU 2003269522 A 20031011; EP 03751517 A 20031011; JP 2004542913 A 20031011; JP 2010015946 A 20100127