Global Patent Index - EP 1560595 A4

EP 1560595 A4 20051228 - FULLY HUMAN ANTIBODY FAB FRAGMENTS WITH HUMAN INTERFERON-GAMMA NEUTRALIZING ACTIVITY

Title (en)

FULLY HUMAN ANTIBODY FAB FRAGMENTS WITH HUMAN INTERFERON-GAMMA NEUTRALIZING ACTIVITY

Title (de)

HUMANES GAMMA-INTERFERON NEUTRALISIERENDE FAB-FRAGMENTE AUS VOLLHUMANEM ANTIKÖRPER

Title (fr)

FRAGMENTS FAB D'ANTICORPS ENTIEREMENT HUMAINS AYANT UNE ACTIVITE DE NEUTRALISATION DE L'INTERFERON-GAMMA HUMAIN

Publication

EP 1560595 A4 20051228 (EN)

Application

EP 02784189 A 20021017

Priority

US 0233556 W 20021017

Abstract (en)

[origin: CA2502668A1] Selective binding agents of interferon-gamma (IFN.UPSILON.) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to IFN.UPSILON. and may be us ed to prevent or treat conditions relating to autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. Nucleic acid molecules encoding said antibodies and antigen binding domains, and expression vectors and host cells for the production of same are also provided.

IPC 1-7

C07K 16/00; A61K 39/395; C07K 14/57; C07K 16/24

IPC 8 full level

A61K 39/395 (2006.01); C07K 14/57 (2006.01); C07K 16/24 (2006.01)

CPC (source: EP)

C07K 16/249 (2013.01); C07K 2317/21 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)

Citation (search report)

  • [Y] WO 0032634 A1 20000608 - PROTEIN DESIGN LABS INC [US], et al
  • [Y] WO 9102005 A1 19910221 - TURANO ADOLFO [IT]
  • [Y] FIORENTINI S ET AL: "A partially humanized monoclonal antibody to human IFN-gamma inhibits cytokine effects both in vitro and in vivo", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 55, no. 3, March 2002 (2002-03-01), pages 284 - 292, XP002347393, ISSN: 0300-9475
  • [A] MAYNARD J ET AL: "ANTIBODY ENGINEERING", ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, ANNUAL REVIEW INCO., PALO ALTO, CA, US, vol. 2, 2000, pages 339 - 376, XP009039750
  • [A] GREEN L L: "Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 231, no. 1-2, 10 December 1999 (1999-12-10), pages 11 - 23, XP004187631, ISSN: 0022-1759
  • [A] GRIFFITHS A D ET AL: "ISOLATION OF HIGH AFFINITY HUMAN ANTIBODIES DIRECTLY FROM LARGE SYNTHETIC REPERTOIRES", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 13, no. 14, 15 July 1994 (1994-07-15), pages 3245 - 3260, XP000455240, ISSN: 0261-4189
  • See references of WO 2004046306A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

DOCDB simple family (publication)

AU 2002347978 A1 20040615; AU 2002347978 B2 20091008; CA 2502668 A1 20040603; CA 2502668 C 20130730; EP 1560595 A2 20050810; EP 1560595 A4 20051228; JP 2006502739 A 20060126; MX PA05003949 A 20050617

DOCDB simple family (application)

AU 2002347978 A 20021017; CA 2502668 A 20021017; EP 02784189 A 20021017; JP 2004553382 A 20021017; MX PA05003949 A 20021017