EP 1560832 B1 20080123 - PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY
Title (en)
PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY
Title (de)
PYRIMIDO 4,5-D PYRIMIDINDERIVATE MITANTIKREBSWIRKUNG
Title (fr)
DERIVES DE PYRIMIDO 4,5-D PYRIMIDINE A ACTIVITE ANTICANCEREUSE
Publication
Application
Priority
- EP 0311896 W 20031027
- US 42367002 P 20021104
Abstract (en)
[origin: WO2004041822A1] Disclosed are novel pyrimido compounds of the formula (I) wherein R<1> to R<9> are as defined in the specification, that are selective inhibitors of both KDR an FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for 10 treating cancer.
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR US)
A61K 31/519 (2013.01 - KR); A61P 35/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 487/04 (2013.01 - EP KR US); G01N 2800/52 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004041822 A1 20040521; AR 041738 A1 20050526; AR 041739 A1 20050526; AT E384725 T1 20080215; AT E386744 T1 20080315; AU 2003274086 A1 20040607; AU 2003274086 B2 20080710; AU 2003276190 A1 20040607; BR 0315912 A 20050913; BR 0316001 A 20050913; CA 2502180 A1 20040521; CA 2502182 A1 20040521; CN 100420688 C 20080924; CN 1711264 A 20051221; CN 1711266 A 20051221; DE 60318888 D1 20080313; DE 60318888 T2 20090108; DE 60319260 D1 20080403; DE 60319260 T2 20090305; EP 1560829 A1 20050810; EP 1560829 B1 20080220; EP 1560832 A1 20050810; EP 1560832 B1 20080123; ES 2298622 T3 20080516; ES 2300609 T3 20080616; JP 2006507292 A 20060302; JP 2006513999 A 20060427; KR 100763299 B1 20071004; KR 100763300 B1 20071004; KR 100774230 B1 20071107; KR 100774231 B1 20071107; KR 20050074534 A 20050718; KR 20050074540 A 20050718; KR 20070087657 A 20070828; KR 20070087689 A 20070828; MX PA05004756 A 20050802; MX PA05004757 A 20050802; PL 376916 A1 20060109; PL 376924 A1 20060109; RU 2005117340 A 20060227; RU 2005117341 A 20060310; RU 2326882 C2 20080620; RU 2331641 C2 20080820; US 2004110773 A1 20040610; US 2005075272 A1 20050407; US 7112676 B2 20060926; US 7129351 B2 20061031; WO 2004041821 A1 20040521
DOCDB simple family (application)
EP 0311896 W 20031027; AR P030103999 A 20031031; AR P030104000 A 20031031; AT 03758072 T 20031027; AT 03810410 T 20031027; AU 2003274086 A 20031027; AU 2003276190 A 20031027; BR 0315912 A 20031027; BR 0316001 A 20031027; CA 2502180 A 20031027; CA 2502182 A 20031027; CN 200380102848 A 20031027; CN 200380102861 A 20031027; DE 60318888 T 20031027; DE 60319260 T 20031027; EP 0311892 W 20031027; EP 03758072 A 20031027; EP 03810410 A 20031027; ES 03758072 T 20031027; ES 03810410 T 20031027; JP 2004548791 A 20031027; JP 2004548792 A 20031027; KR 20057007906 A 20050504; KR 20057007981 A 20050504; KR 20077016286 A 20070716; KR 20077017255 A 20070726; MX PA05004756 A 20031027; MX PA05004757 A 20031027; PL 37691603 A 20031027; PL 37692403 A 20031027; RU 2005117340 A 20031027; RU 2005117341 A 20031027; US 68923503 A 20031020; US 68943803 A 20031020