Global Patent Index - EP 1560925 A4

EP 1560925 A4 20061025 - INHIBITORS OF INFLAMMATORY GENE ACTIVITY AND CHOLESTEROL BIOSYNTHESIS

Title (en)

INHIBITORS OF INFLAMMATORY GENE ACTIVITY AND CHOLESTEROL BIOSYNTHESIS

Title (de)

INHIBITOREN VON ENTZÜNDLICHER GENAKTIVITÄT UND CHOLESTERINBIOSYNTHESE

Title (fr)

INHIBITEURS DE L'ACTIVITE GENIQUE INFLAMMATOIRE ET DE LA SYNTHESE DE CHOLESTEROL

Publication

EP 1560925 A4 20061025 (EN)

Application

EP 03760319 A 20030613

Priority

  • US 0318651 W 20030613
  • US 38791502 P 20020613
  • US 47018803 P 20030514

Abstract (en)

[origin: US2005221328A1] Methods of identifying agents effective as inhibitors of short heterodimer protein (SHP) and farnesoid X receptor (FXR) and promoters, cell lines and vectors used in said methods. Methods of preparing and using the agents effective as inhibitors of short heterodimer protein (SHP), including methods of using same to prevent and/or treat a condition associated with inflammatory gene activity and/or cholesterol biosynthesis in a subject. Agents effective as inhibitors of short heterodimer protein (SHP) and farnesoid X receptor (FXR) and compositions comprising same, including compositions effective in reducing inflammatory gene activity and/or cholesterol biosynthesis in a subject.

IPC 1-7

C12Q 1/68; A01N 43/04; C07H 21/04; A61K 31/07

IPC 8 full level

A01N 43/04 (2006.01); A61K 31/07 (2006.01); C07H 21/04 (2006.01); C07K 14/47 (2006.01); C07K 14/70 (2006.01); C12N 15/11 (2006.01); C12N 15/85 (2006.01); C12Q 1/68 (2006.01); G01N 33/92 (2006.01)

CPC (source: EP KR US)

A61K 31/07 (2013.01 - KR); A61P 3/06 (2017.12 - EP); A61P 29/00 (2017.12 - EP); C12Q 1/6883 (2013.01 - KR); C12Q 1/6897 (2013.01 - KR); G01N 33/92 (2013.01 - EP KR US); G01N 2500/10 (2013.01 - EP KR US); G01N 2800/044 (2013.01 - EP KR US)

Citation (search report)

  • [X] WO 0153312 A1 20010726 - HYSEQ INC [US], et al
  • [X] US 5728548 A 19980317 - BOWMAN MICHAEL [US]
  • [X] WO 0232410 A2 20020425 - IMP COLLEGE INNOVATIONS LTD [GB], et al
  • [X] WO 0179224 A2 20011025 - GENAISSANCE PHARMACEUTICALS [US], et al
  • [X] EP 0648840 A2 19950419 - UNIV NORTHEASTERN OHIO [US]
  • [X] WO 0210769 A2 20020207 - GLAXO GROUP LTD [GB], et al
  • [XY] KIM Y S ET AL: "The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 7 SEP 2001, vol. 276, no. 36, 7 September 2001 (2001-09-07), pages 33736 - 33740, XP002388945, ISSN: 0021-9258
  • [XY] MORI N ET AL: "ACTIVATION OF INTERCELLULAR ADHESION MOLECULE 1 EXPRESSION BY HELICOBACTER PYLORI IS REGULATED BY NF-KAPPAB IN GASTRIC EPITHELIAL CANCER CELLS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 68, no. 4, April 2000 (2000-04-01), pages 1806 - 1814, XP001164217, ISSN: 0019-9567
  • [X] DATABASE WPI Week 2001, Derwent World Patents Index; AN 2001-112080, XP002389087
  • [A] BERGHE WIM VANDEN ET AL: "Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism", MOLECULAR PHARMACOLOGY, vol. 56, no. 4, October 1999 (1999-10-01), pages 797 - 806, XP002388944, ISSN: 0026-895X
  • [X] CHEN W ET AL: "Nuclear receptor-mediated repression of human cholesterol 7-alpha hydroxylase gene transcription by bile acids", JOURNAL OF LIPID RESEARCH, BETHESDA, MD, US, vol. 42, 2001, pages 1402 - 1412, XP002970739, ISSN: 0022-2275
  • [X] ZHANG M ET AL: "Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 9 NOV 2001, vol. 276, no. 45, 9 November 2001 (2001-11-09), pages 41690 - 41699, XP002397840, ISSN: 0021-9258
  • [X] LEE Y K ET AL: "Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 23 JUL 1999, vol. 274, no. 30, 23 July 1999 (1999-07-23), pages 20869 - 20873, XP002397841, ISSN: 0021-9258
  • [X] LEE H-K ET AL: "Structure and expression of the orphan nuclear receptor SHP gene", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 273, no. 23, 5 June 1998 (1998-06-05), pages 14398 - 14402, XP002339263, ISSN: 0021-9258 & WO 0071697 A1 20001130 - SANKYO CO [JP], et al
  • See references of WO 03106632A2

Citation (examination)

  • WO 0210769 A2 20020207 - GLAXO GROUP LTD [GB], et al
  • LEE Y.K. ET AL: "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 1, January 2000 (2000-01-01), pages 187 - 195

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

US 2005221328 A1 20051006; BR 0311772 A 20070508; CA 2489594 A1 20031224; CN 1675376 A 20050928; EA 200500012 A1 20060428; EP 1560925 A2 20050810; EP 1560925 A4 20061025; JP 2006505249 A 20060216; KR 20050010916 A 20050128; MX PA04012560 A 20051019; NO 20045536 L 20050228

DOCDB simple family (application)

US 51769504 A 20041213; BR 0311772 A 20030613; CA 2489594 A 20030613; CN 03819498 A 20030613; EA 200500012 A 20030613; EP 03760319 A 20030613; JP 2004513445 A 20030613; KR 20047020311 A 20030613; MX PA04012560 A 20030613; NO 20045536 A 20041217