EP 1562978 A4 20071010 - RAPID INDUCTION OF ALZHEIMER S AMYLOID PLAQUE FORMATION BY SULFATED GLYCOSAMINOGLYCANS
Title (en)
RAPID INDUCTION OF ALZHEIMER S AMYLOID PLAQUE FORMATION BY SULFATED GLYCOSAMINOGLYCANS
Title (de)
SCHNELLE INDUKTION VONALZHEIMER-AMYLOIDPLAQUEBILDUNG DURCH SULFATIERTE GLYCOSAMINOGLYCANE
Title (fr)
INDUCTION RAPIDE DE LA FORMATION DE LA PLAQUE AMYLOIDE D'ALZHEIMER PAR DES GLYCOSAMINOGLYCANES SULFATES
Publication
Application
Priority
- US 0334797 W 20031031
- US 42318502 P 20021101
Abstract (en)
[origin: WO2004041779A2] A method of induction of amyloid plaques includes immobilizing a quantity of a selected sulfated glycosaminoglycan (SGAG) on a selected medium and adding to the immobilized SGAG on the medium a quantity of dissolved low fibrillar Aß 1-40 (LFAß). The LFAß is added preferably in a Aß:SGAG w/w ratio of about 1:1. SGAGs are preferably selected from heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chondroitin-4-sulfate and chondroitin-6-sulfate. Screening methods and kits for screening either immobilize a quantity of a selected sulfated glycosaminoglycan (SGAG) on a selected medium, followed by adding to a quantity of dissolved low fibrillar Aß 1-40 (LFAß) a selected quantity of the selected amyloid therapeutic candidate to create a test solution, and then adding to the immobilized SGAG on the medium a selected quantity of the test solution to test for inhibition, or preform amyloid plaques on the medium by immobilizing a quantity of a selected sulfated glycosaminoglycan (SLAG) or a GAG-related macromolecule on a selected medium and then adding a selected quantity of dissolved low fibrillar Aß 1-40 (LFAß), followed by adding to the amyloid plaques on the medium a selected quantity of a test solution of a selected amyloid therapeutic candidate to test for disruption.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07K 14/4711 (2013.01); G01N 33/6896 (2013.01); G01N 2400/40 (2013.01); G01N 2500/04 (2013.01)
Citation (search report)
- [A] WO 9945947 A1 19990916 - UNIV WASHINGTON [US]
- [A] WO 9744669 A1 19971127 - MEDICAL RES COUNCIL [GB], et al
- See references of WO 2004041779A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004041779 A2 20040521; WO 2004041779 A3 20050113; AU 2003286845 A1 20040607; AU 2003286845 A8 20040607; CA 2504035 A1 20040521; EP 1562978 A2 20050817; EP 1562978 A4 20071010; JP 2006507488 A 20060302; JP 4469281 B2 20100526
DOCDB simple family (application)
US 0334797 W 20031031; AU 2003286845 A 20031031; CA 2504035 A 20031031; EP 03778061 A 20031031; JP 2004550393 A 20031031