EP 1567178 A4 20090715 - MODULATORS OF RECEPTORS FOR PARATHYROIS HORMONE AND PARATHYROID HORMONE-RELATED PROTEIN
Title (en)
MODULATORS OF RECEPTORS FOR PARATHYROIS HORMONE AND PARATHYROID HORMONE-RELATED PROTEIN
Title (de)
MODULATOREN VON REZEPTOREN FÜR NEBENSCHILDDRÜSENHORMON- UND NEBENSCHILDSRÜSENHORMONBEZOGENE PROTEINE
Title (fr)
MODULATEURS DE RECEPTEURS DE L'HORMONE PARATHYROIDE ET DE LA PROTEINE LIEE A L'HORMONE PARATHYROIDE
Publication
Application
Priority
US 0236419 W 20021101
Abstract (en)
[origin: WO2004060386A1] The present invention concerns therapeutic agents that modulate the activity of PTH and PTHrP. In accordance with the present invention, modulators of PTH and PTHrP comprise: (a) a PTH/PTHrP modulating domain; and (b) a vehicle, such as a polymer (e.g., PEG or dextran) or an Fc domain, which is preferred; wherein the vehicle is covalently attached, to the C-terminus of the PTH/PTHrP modulating domain or through a sidechain at any residue from residue 14 through the C-terminal residue. The vehicle and the PTH/PTHrP modulating domain may be linked through the N- or C terminus of the PTH/PTHrP modulating domain, as described further below. The preferred vehicle is PEG. Preferred PTH/PTHrP modulating domains comprise the PTH and PTHrP-derived amino acid sequences described hereinafter. Other PTH/PTHrP modulating domains can be generated by phage display, RNA-peptide screening and the other techniques mentioned herein. Such peptides typically will be modulators of both PTH activity and PTHrP activity, although such techniques can be used to generate peptide sequences that serve as selective modulators (e.g., agonists of PTH activity but not PTHrP activity).
IPC 1-7
A61K 38/00; A61K 38/24; A61K 38/27; A61K 39/00; A61K 39/395; C07K 1/00; C07K 14/00; C07K 16/00; C07K 17/00
IPC 8 full level
A61K 38/29 (2006.01); A61K 47/48 (2006.01); C07K 14/635 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
A61K 38/29 (2013.01); A61K 47/60 (2017.08); C07K 14/635 (2013.01); A61K 39/00 (2013.01)
Citation (search report)
- [X] WO 9306846 A1 19930415 - PANG PETER K T [CA]
- [X] WO 9805683 A1 19980212 - CA NAT RESEARCH COUNCIL [CA], et al
- [X] WO 02068459 A2 20020906 - CLONTECH LAB INC [US], et al
- [X] WO 0181415 A2 20011101 - AMGEN INC [US]
- [X] BARBIER JEAN-RENE ET AL: "Structure and activities of constrained analogues of human parathyroid hormone and parathyroid hormone-related peptide: Implications for receptor-activating conformations of the hormones", BIOCHEMISTRY, vol. 39, no. 47, 28 November 2000 (2000-11-28), pages 14522 - 14530, XP002530193, ISSN: 0006-2960
- [X] KINSTLER O ET AL: "Mono-N-terminal poly(ethylene glycol)-protein conjugates", ADVANCED DRUG DELIVERY REVIEWS 20020617 NL, vol. 54, no. 4, 17 June 2002 (2002-06-17), pages 477 - 485, XP002530194, ISSN: 0169-409X
- See also references of WO 2004060386A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 2004060386 A1 20040722; AU 2002359391 A1 20040729; CA 2511966 A1 20040722; EP 1567178 A1 20050831; EP 1567178 A4 20090715
DOCDB simple family (application)
US 0236419 W 20021101; AU 2002359391 A 20021101; CA 2511966 A 20021101; EP 02793926 A 20021101