EP 1567641 A2 20050831 - PROAEROLYSIN CONTAINING PROTEASE ACTIVATION SEQUENCES AND METHODS OF USE FOR TREATMENT OF PROSTATE CANCER
Title (en)
PROAEROLYSIN CONTAINING PROTEASE ACTIVATION SEQUENCES AND METHODS OF USE FOR TREATMENT OF PROSTATE CANCER
Title (de)
PROAEROLYSIN ENTHALTENDE PROTEASEAKTIVIERUNGSSEQUENZEN UND VERFAHREN ZUR ANWENDUNG BEI DER BEHANDLUNG VON PROSTATAKREBS
Title (fr)
PROAEROLYSINE CONTENANT DES SEQUENCES D'ACTIVATION DE PROTEASE ET PROCEDES DESTINES AU TRAITEMENT DU CANCER DE LA PROSTATE
Publication
Application
Priority
- US 0227061 W 20020823
- US 31461301 P 20010824
Abstract (en)
[origin: WO03018611A2] Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
IPC 1-7
C12N 9/52; C12N 15/57; C12N 15/62; C07K 14/32; C07K 14/33; C07K 19/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 13/08 (2006.01); A61P 35/00 (2006.01); C07K 7/06 (2006.01); C07K 14/195 (2006.01); C07K 14/32 (2006.01); C07K 14/325 (2006.01); C07K 14/33 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 9/52 (2006.01)
CPC (source: EP US)
A61K 39/001193 (2018.08 - EP US); A61K 39/001194 (2018.08 - EP US); A61K 39/001195 (2018.08 - EP US); A61P 13/08 (2018.01 - EP); A61P 35/00 (2018.01 - EP); C07K 14/195 (2013.01 - EP US); C07K 14/32 (2013.01 - EP US); C07K 14/325 (2013.01 - EP US); C07K 14/33 (2013.01 - EP US); C12N 9/52 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03018611 A2 20030306; WO 03018611 A3 20050630; AU 2002331720 B2 20071011; CA 2457903 A1 20030306; CA 2457903 C 20180417; CN 100488981 C 20090520; CN 1636017 A 20050706; DK 1567641 T3 20120827; EP 1567641 A2 20050831; EP 1567641 A4 20051228; EP 1567641 B1 20120523; EP 2518142 A1 20121031; EP 2518142 B1 20150715; ES 2388170 T3 20121009; ES 2542888 T3 20150812; HK 1178563 A1 20130913; JP 2005520490 A 20050714; JP 4319908 B2 20090826; PT 1567641 E 20120821; US 2004235095 A1 20041125; US 2008089869 A1 20080417; US 2010234300 A1 20100916; US 7282476 B2 20071016; US 7745395 B2 20100629; US 7838266 B2 20101123; ZA 200402319 B 20050830
DOCDB simple family (application)
US 0227061 W 20020823; AU 2002331720 A 20020823; CA 2457903 A 20020823; CN 02816622 A 20020823; DK 02768702 T 20020823; EP 02768702 A 20020823; EP 10177191 A 20020823; ES 02768702 T 20020823; ES 10177191 T 20020823; HK 13105243 A 20130430; JP 2003523270 A 20020823; PT 02768702 T 20020823; US 48711504 A 20040218; US 78891310 A 20100527; US 85654307 A 20070917; ZA 200402319 A 20040323