EP 1569684 A4 20060802 - USE OF HMGB FRAGMENTS AS ANTI-INFLAMMATORY AGENTS
Title (en)
USE OF HMGB FRAGMENTS AS ANTI-INFLAMMATORY AGENTS
Title (de)
VERWENDUNG VONHMGB-FRAGMENTEN ALS ENTZÜNDUNGSHEMMENDE MITTEL
Title (fr)
UTILISATION DE FRAGMENTS HMGB EN TANT QU'AGENTS ANTI-INFLAMMATOIRES
Publication
Application
Priority
- US 0337507 W 20031120
- US 42784102 P 20021120
- US 42784602 P 20021120
Abstract (en)
[origin: WO2004046345A2] Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise an HMGB A box, and/or an antibody preparation that specifically binds to an HMGB B box, and/or an inhibitor of TNF biological activity. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
IPC 1-7
IPC 8 full level
A61K 38/17 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); A61P 1/04 (2017.12); A61P 1/18 (2017.12); A61P 3/04 (2017.12); A61P 9/00 (2017.12); A61P 9/02 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 19/00 (2017.12); A61P 25/00 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 31/04 (2017.12); A61P 35/00 (2017.12); A61P 37/04 (2017.12); A61P 43/00 (2017.12); C07K 14/47 (2013.01)
Citation (search report)
- [X] ROGALLA P ET AL: "Mapping and molecular characterization of five HMG1-related DNA sequences", CYTOGENETICS AND CELL GENETICS, vol. 83, no. 1-2, 1998, pages 124 - 129, XP009063822, ISSN: 0301-0171
- [X] DATABASE Geneseq [online] 6 October 2000 (2000-10-06), "Human secreted protein, SEQ ID NO: 7904.", XP002373264, retrieved from EBI accession no. GSN:AAG03823 Database accession no. AAG03823
- [A] DAILEY LISA ET AL: "Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 186, no. 3, March 2001 (2001-03-01), pages 315 - 328, XP002373261, ISSN: 0021-9541
- [T] YANG HUAN ET AL: "Reversing established sepsis with antagonists of endogenous high-mobility group box 1.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 1, 6 January 2004 (2004-01-06), pages 296 - 301, XP002373262, ISSN: 0027-8424 & EP 1033401 A2 20000906 - GENSET SA [FR]
- See references of WO 2004046345A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004046345 A2 20040603; WO 2004046345 A3 20041202; AU 2003294488 A1 20040615; AU 2003294488 B2 20070524; CA 2506328 A1 20040603; EP 1569684 A2 20050907; EP 1569684 A4 20060802; JP 2006510619 A 20060330; NZ 540067 A 20070531
DOCDB simple family (application)
US 0337507 W 20031120; AU 2003294488 A 20031120; CA 2506328 A 20031120; EP 03789973 A 20031120; JP 2004554020 A 20031120; NZ 54006703 A 20031120